Abstract
Synthetically useful β,γ-unsaturated carbonyl compounds having a quaternary carbon at the α-position were prepared with high stereoselectivity by the reaction of a dienolate anion derived from α,β-unsaturated imide having a chiral auxiliary and electrophiles (ethyl acetate and allyl iodide as the C2 and C3 unit, respectively). This method was applied to a short asymmetric synthesis of (+)-ethosuximide.
Original language | English |
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Pages (from-to) | 9303-9305 |
Number of pages | 3 |
Journal | Tetrahedron Letters |
Volume | 44 |
Issue number | 52 |
DOIs | |
Publication status | Published - 2003 Dec 22 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry