Stereotactic radiosurgery of essential trigeminal neuralgia using Leksell Gamma Knife model C with automatic positioning system: Technical nuances and evaluation of outcome in 130 patients with at least 2 years follow-up after treatment

Motohiro Hayashi, Mikhail Chernov, Noriko Tamura, Takaomi Taira, Masahiro Izawa, Shoji Yomo, Mariko Nagai, Cheng Siu Chang, Pavel Ivanov, Manabu Tamura, Yoshihiro Muragaki, Yoshikazu Okada, Hiroshi Iseki, Kintomo Takakura

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The objective of the present study was the evaluation of outcome in 130 patients with essential trigeminal neuralgia, who were treated using Leksell Gamma Knife model C with automatic positioning system and followed at least 24 months thereafter. Radiosurgery was guided by fused thin-sliced magnetic resonance (MR) and "bone window" computed tomographic (CT) images. In all cases, retrogasserian part of the trigeminal nerve at the level of trigeminal incisura was selected as a target, and one 4-mm collimator was used for delivery of the maximum irradiation dose of 90 Gy. The coordinates of the isocenter were adjusted for positioning of the nerve in the center of 80% isodose area, and were corrected in each individual case with regard to presence of distortion artifacts on MR images. Initial relief of the typical paroxysmal facial pain was marked in 127 patients (98%) within a median interval of 3 weeks after treatment. However, in 23 patients the pain re-appeared later on. Overall, at the time of the last follow-up 112 patients (86%) were painfree, including 86 who remained both pain-and medicationfree after initial radiosurgery. In 31 cases (24%), treatment was complicated by facial hypesthesia and/or paresthesia. In conclusion, radiosurgery of essential trigeminal neuralgia results in a high rate of initial pain relief, but pain recurrences and associated complications are not uncommon. The outcome may be influenced by various technical nuances; therefore, treatment should be preferably done in specialized clinical centers with sufficient expertise in the management of this disorder.

Original languageEnglish
Pages (from-to)497-508
Number of pages12
JournalNeurosurgical Review
Volume34
Issue number4
DOIs
Publication statusPublished - 2011 Oct
Externally publishedYes

Fingerprint

Trigeminal Neuralgia
Radiosurgery
Pain
Magnetic Resonance Spectroscopy
Facial Pain
Trigeminal Nerve
Hypesthesia
Paresthesia
Therapeutics
Artifacts
Bone and Bones
Recurrence

Keywords

  • Automatic positioning system
  • Gamma Knife surgery
  • Outcome
  • Stereotactic radiosurgery
  • Treatment
  • Trigeminal neuralgia

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Stereotactic radiosurgery of essential trigeminal neuralgia using Leksell Gamma Knife model C with automatic positioning system : Technical nuances and evaluation of outcome in 130 patients with at least 2 years follow-up after treatment. / Hayashi, Motohiro; Chernov, Mikhail; Tamura, Noriko; Taira, Takaomi; Izawa, Masahiro; Yomo, Shoji; Nagai, Mariko; Chang, Cheng Siu; Ivanov, Pavel; Tamura, Manabu; Muragaki, Yoshihiro; Okada, Yoshikazu; Iseki, Hiroshi; Takakura, Kintomo.

In: Neurosurgical Review, Vol. 34, No. 4, 10.2011, p. 497-508.

Research output: Contribution to journalArticle

Hayashi, Motohiro ; Chernov, Mikhail ; Tamura, Noriko ; Taira, Takaomi ; Izawa, Masahiro ; Yomo, Shoji ; Nagai, Mariko ; Chang, Cheng Siu ; Ivanov, Pavel ; Tamura, Manabu ; Muragaki, Yoshihiro ; Okada, Yoshikazu ; Iseki, Hiroshi ; Takakura, Kintomo. / Stereotactic radiosurgery of essential trigeminal neuralgia using Leksell Gamma Knife model C with automatic positioning system : Technical nuances and evaluation of outcome in 130 patients with at least 2 years follow-up after treatment. In: Neurosurgical Review. 2011 ; Vol. 34, No. 4. pp. 497-508.
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abstract = "The objective of the present study was the evaluation of outcome in 130 patients with essential trigeminal neuralgia, who were treated using Leksell Gamma Knife model C with automatic positioning system and followed at least 24 months thereafter. Radiosurgery was guided by fused thin-sliced magnetic resonance (MR) and {"}bone window{"} computed tomographic (CT) images. In all cases, retrogasserian part of the trigeminal nerve at the level of trigeminal incisura was selected as a target, and one 4-mm collimator was used for delivery of the maximum irradiation dose of 90 Gy. The coordinates of the isocenter were adjusted for positioning of the nerve in the center of 80{\%} isodose area, and were corrected in each individual case with regard to presence of distortion artifacts on MR images. Initial relief of the typical paroxysmal facial pain was marked in 127 patients (98{\%}) within a median interval of 3 weeks after treatment. However, in 23 patients the pain re-appeared later on. Overall, at the time of the last follow-up 112 patients (86{\%}) were painfree, including 86 who remained both pain-and medicationfree after initial radiosurgery. In 31 cases (24{\%}), treatment was complicated by facial hypesthesia and/or paresthesia. In conclusion, radiosurgery of essential trigeminal neuralgia results in a high rate of initial pain relief, but pain recurrences and associated complications are not uncommon. The outcome may be influenced by various technical nuances; therefore, treatment should be preferably done in specialized clinical centers with sufficient expertise in the management of this disorder.",
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