TY - GEN
T1 - Steroid biosynthesis within the frog brain
T2 - A model of neuroendocrine regulation
AU - Do Rego, Jean Luc
AU - Seong, Jae Young
AU - Burel, Delphine
AU - Luu-The, Van
AU - Larhammar, Dan
AU - Tsutsui, Kazuyoshi
AU - Pelletier, Georges
AU - Tonon, Marie Christine
AU - Vaudry, Hubert
PY - 2009/4
Y1 - 2009/4
N2 - There is now clear evidence that the brain, similar to the adrenal gland, gonads, and placenta, is a steroidogenic organ. Notably in the frog brain, the presence of various steroidogenic enzymes has been detected by immunohistochemistry in specific populations of neurons and/or glial cells. These steroidogenic enzymes are biologically active, as shown by the ability of brain tissue explants to convert [3H]pregnenolone into various radiolabeled steroids. The frog brain has also been extensively used as a model to study the mechanism of regulation of neurosteroidogenesis by neurotransmitters and neuropeptides. It has been demonstrated that the biosynthesis of neurosteroids is inhibited by γ-aminobutyric acid (GABA), acting through GABAA receptors, and neuropeptide Y, acting through Y1 receptors, and is stimulated by the octadecaneuropeptide (ODN), acting through central-type benzodiazepine receptors, triakontatetraneuropeptide (TTN), acting through peripheral-type benzodiazepine receptors, and vasotocin, acting through V1a-like receptors. These data indicate that some of the neurophysiological effects of neurotransmitters and neuropeptides may be mediated through modulation of neurosteroid biosynthesis.
AB - There is now clear evidence that the brain, similar to the adrenal gland, gonads, and placenta, is a steroidogenic organ. Notably in the frog brain, the presence of various steroidogenic enzymes has been detected by immunohistochemistry in specific populations of neurons and/or glial cells. These steroidogenic enzymes are biologically active, as shown by the ability of brain tissue explants to convert [3H]pregnenolone into various radiolabeled steroids. The frog brain has also been extensively used as a model to study the mechanism of regulation of neurosteroidogenesis by neurotransmitters and neuropeptides. It has been demonstrated that the biosynthesis of neurosteroids is inhibited by γ-aminobutyric acid (GABA), acting through GABAA receptors, and neuropeptide Y, acting through Y1 receptors, and is stimulated by the octadecaneuropeptide (ODN), acting through central-type benzodiazepine receptors, triakontatetraneuropeptide (TTN), acting through peripheral-type benzodiazepine receptors, and vasotocin, acting through V1a-like receptors. These data indicate that some of the neurophysiological effects of neurotransmitters and neuropeptides may be mediated through modulation of neurosteroid biosynthesis.
KW - Amphibians
KW - Brain
KW - Neuropeptides
KW - Neurosteroids
KW - Neurotransmitters
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U2 - 10.1111/j.1749-6632.2008.03664.x
DO - 10.1111/j.1749-6632.2008.03664.x
M3 - Conference contribution
C2 - 19456330
AN - SCOPUS:65449116901
SN - 9781573316712
VL - 1163
T3 - Annals of the New York Academy of Sciences
SP - 83
EP - 92
BT - Annals of the New York Academy of Sciences
ER -