Stimulation of the 5-HT(1A) receptor selectively suppresses NMDA receptor-mediated synaptic excitation in the rat visual cortex

Yoshikuni Edagawa, Hiroshi Saito, Kazuho Abe

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

We have previously found that stimulation of serotonin 5-HT(1A) receptors inhibits the induction of long-term potentiation (LTP) in the rat visual cortex. In the present study, the selective 5-HT(1A) receptor agonist 8-hydroxy-2-(N,N-dipropylamino)tetralin (8-OH-DPAT) significantly reduced N- methyl-D-aspartate (NMDA) receptor-mediated synaptic responses recorded in Mg2+-free medium in rat visual cortical slices. In addition, there was good correlation between the inhibitory effects of 8-OH-DPAT on NMDA responses and LTP. These results suggest that 5-HT(1A) receptor stimulation inhibits the induction of LTP by suppressing NMDA receptor-mediated synaptic excitation in the rat visual cortex.

Original languageEnglish
Pages (from-to)225-228
Number of pages4
JournalBrain Research
Volume827
Issue number1-2
DOIs
Publication statusPublished - 1999 May 8
Externally publishedYes

Keywords

  • 8-Hydroxy-2-(N,N-dipropylamino)tetralin (8- OH-DPAT)
  • Long-term potentiation
  • N-methyl-D-aspartate receptor
  • Serotonin 5-HT(1A) receptor
  • Visual cortex

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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