Stochastic determinism underlying life: Systematic theory for assisting the synthesis of artificial cells and new medicines

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    22 Citations (Scopus)

    Abstract

    The frequencies of purines and pyrimidines in double-strand DNA are in a symmetric ratio of 1: 1, while the asymmetric density ratios of purines and pyrimidines in RNA and artificial ribozymes are between 1: 1 and approximately 1: 1.5. The frequency ratio in DNA is deterministic, while that in RNA is fairly stochastic. Symbiotic fusion of deterministic symmetry and stochastic asymmetry, which can be seen at the molecular, cell and whole-body levels, is a key concept for understanding the self-organizing processes in living organisms. The left-right symmetric distribution of arms and legs is observed in outward appearance, although the inner body, including the heart and the liver, is asymmetric. A minimum hypercycle of four cycles at the origin of life is also in the symbiotic fusion of symmetry and asymmetry. The inevitability of deterministic symmetry and stochastic asymmetry underlying life is systematically revealed on the basis of physics as the weft and molecular biology as the warp.

    Original languageEnglish
    Pages (from-to)10-17
    Number of pages8
    JournalArtificial Life and Robotics
    Volume13
    Issue number1
    DOIs
    Publication statusPublished - 2008

    Fingerprint

    Artificial Cells
    Pyrimidines
    Purines
    RNA
    Medicine
    DNA
    Fusion reactions
    Catalytic RNA
    Molecular biology
    Physics
    Liver
    Molecular Biology
    Leg
    Arm
    Origin of Life
    Cell Body
    Body Physical Appearance

    Keywords

    • Asymmetry
    • Inevitability
    • Origin
    • Stochastic determinism
    • Symmetry

    ASJC Scopus subject areas

    • Artificial Intelligence
    • Biochemistry, Genetics and Molecular Biology(all)

    Cite this

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    abstract = "The frequencies of purines and pyrimidines in double-strand DNA are in a symmetric ratio of 1: 1, while the asymmetric density ratios of purines and pyrimidines in RNA and artificial ribozymes are between 1: 1 and approximately 1: 1.5. The frequency ratio in DNA is deterministic, while that in RNA is fairly stochastic. Symbiotic fusion of deterministic symmetry and stochastic asymmetry, which can be seen at the molecular, cell and whole-body levels, is a key concept for understanding the self-organizing processes in living organisms. The left-right symmetric distribution of arms and legs is observed in outward appearance, although the inner body, including the heart and the liver, is asymmetric. A minimum hypercycle of four cycles at the origin of life is also in the symbiotic fusion of symmetry and asymmetry. The inevitability of deterministic symmetry and stochastic asymmetry underlying life is systematically revealed on the basis of physics as the weft and molecular biology as the warp.",
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