Stochasticity of the step size in the force generating process due to a single myosin molecule

Yuki Kagawa, Yoshimi Tsuchiya

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We formulate a motional model on the basis of an experimental optical trapping system which reveals the single molecular events of the force generation due to actin and myosin, and we discuss the origin of the dispersion of the displacements of the beads bound to the actin filament. In some experimental data sets, this dispersion is larger than that presumed from the model under the condition that the thermal agitation is the only source of the fluctuation. Thus, other fluctuating elements besides that due to thermal agitation are supposed to cause the dispersion. A possible fluctuating element is the step size itself. We discuss this possibility and estimate the fluctuation in step size using two reported experimental data sets.

Original languageEnglish
Pages (from-to)407-419
Number of pages13
JournalBulletin of Mathematical Biology
Volume64
Issue number2
DOIs
Publication statusPublished - 2002 Mar

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Myosin
Stochasticity
Myosins
stochasticity
myosin
Hot Temperature
Actin
agitation
Molecules
Optical Tweezers
Optical Devices
Actins
Actin Cytoskeleton
Experimental Data
Fluctuations
Optical Trapping
heat
Filament
microfilaments
actin

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Stochasticity of the step size in the force generating process due to a single myosin molecule. / Kagawa, Yuki; Tsuchiya, Yoshimi.

In: Bulletin of Mathematical Biology, Vol. 64, No. 2, 03.2002, p. 407-419.

Research output: Contribution to journalArticle

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