Stretchable substrates for the measurement of intracellular calcium ion concentration responding to mechanical stress

Y. J. Heo, Eiji Iwase, K. Matsumoto, I. Shimoyama

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Citations (Scopus)

Abstract

This paper presents the design, fabrication, and the characterization of a stretchable substrate, achieving the change of intracellular calcium ion concentration by mechanical stress. We propose the stretchable substrate integrated with the air chambers of the pneumatic actuator. We have measured the areal strain depending on input pressure and the intracellular calcium ion concentration increase in response to the mechanical stress. The present stretchable substrate is able to provide the areal strain of 5.21%~12.3% for the input pressure of 34.5kPa~103kPa. We also verified that the present stretchable substrate is able to stimulate cells by the mechanical stress applied through integrins, showing potential feasible application for monitoring the calcium ion influx caused by the mechanical stress.

Original languageEnglish
Title of host publicationProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Pages68-71
Number of pages4
DOIs
Publication statusPublished - 2009
Externally publishedYes
Event22nd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2009 - Sorrento, Italy
Duration: 2009 Jan 252009 Jan 29

Other

Other22nd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2009
CountryItaly
CitySorrento
Period09/1/2509/1/29

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ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Mechanical Engineering
  • Condensed Matter Physics
  • Electronic, Optical and Magnetic Materials

Cite this

Heo, Y. J., Iwase, E., Matsumoto, K., & Shimoyama, I. (2009). Stretchable substrates for the measurement of intracellular calcium ion concentration responding to mechanical stress. In Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS) (pp. 68-71). [4805321] https://doi.org/10.1109/MEMSYS.2009.4805321