Stretchable substrates using pneumatic actuators for monitoring mechanical-stress-dependent cell response

Yun Jung Heo, Eiji Iwase, Kiyoshi Matsumoto, Isao Shimoyama

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

We present a stretchable substrate integrated with pneumatic actuators, designed to be able to supply mechanical stress to live cells on a microchip. The fabricated substrate shows areal strain of 2.49∼5.88% for input pressure of 5∼30psi. The fibroblasts plated on the present devices are stretched for the input pressure. Therefore, we experimentally verified that the fabricated stretchable substrates are able to culture and stretch the fibroblasts, showing potential applications for monitoring the mechanical-stress-dependent cell response.

Original languageEnglish
Title of host publication12th International Conference on Miniaturized Systems for Chemistry and Life Sciences - The Proceedings of MicroTAS 2008 Conference
PublisherChemical and Biological Microsystems Society
Pages579-581
Number of pages3
Publication statusPublished - 2008
Externally publishedYes
Event12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008 - San Diego, CA
Duration: 2008 Oct 122008 Oct 16

Other

Other12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008
CitySan Diego, CA
Period08/10/1208/10/16

Fingerprint

Pneumatic actuators
Fibroblasts
Monitoring
Substrates
Cell culture

Keywords

  • Mechanical stress
  • Pneumatic actuator
  • Stretchable substrate

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

Cite this

Heo, Y. J., Iwase, E., Matsumoto, K., & Shimoyama, I. (2008). Stretchable substrates using pneumatic actuators for monitoring mechanical-stress-dependent cell response. In 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences - The Proceedings of MicroTAS 2008 Conference (pp. 579-581). Chemical and Biological Microsystems Society.

Stretchable substrates using pneumatic actuators for monitoring mechanical-stress-dependent cell response. / Heo, Yun Jung; Iwase, Eiji; Matsumoto, Kiyoshi; Shimoyama, Isao.

12th International Conference on Miniaturized Systems for Chemistry and Life Sciences - The Proceedings of MicroTAS 2008 Conference. Chemical and Biological Microsystems Society, 2008. p. 579-581.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Heo, YJ, Iwase, E, Matsumoto, K & Shimoyama, I 2008, Stretchable substrates using pneumatic actuators for monitoring mechanical-stress-dependent cell response. in 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences - The Proceedings of MicroTAS 2008 Conference. Chemical and Biological Microsystems Society, pp. 579-581, 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008, San Diego, CA, 08/10/12.
Heo YJ, Iwase E, Matsumoto K, Shimoyama I. Stretchable substrates using pneumatic actuators for monitoring mechanical-stress-dependent cell response. In 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences - The Proceedings of MicroTAS 2008 Conference. Chemical and Biological Microsystems Society. 2008. p. 579-581
Heo, Yun Jung ; Iwase, Eiji ; Matsumoto, Kiyoshi ; Shimoyama, Isao. / Stretchable substrates using pneumatic actuators for monitoring mechanical-stress-dependent cell response. 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences - The Proceedings of MicroTAS 2008 Conference. Chemical and Biological Microsystems Society, 2008. pp. 579-581
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