Striatonigral direct pathway activation is sufficient to induce repetitive behaviors

Youcef Bouchekioua, Iku Tsutsui-Kimura, Hiromi Sano, Miwako Koizumi, Kenji F. Tanaka, Keitaro Yoshida, Yutaka Kosaki, Shigeru Watanabe, Masaru Mimura

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Pharmacological intervention in the substantia nigra is known to induce repetitive behaviors in rodents, but a direct causal relationship between a specific neural circuit and repetitive behavior has not yet been established. Here we demonstrate that optogenetic activation of dopamine D1 receptor-expressing MSNs terminals in the substantia nigra pars reticulata resulted in sustained and chronic repetitive behaviors. These data show for the first time that activation of the striatonigral direct pathway is sufficient to generate motor stereotypies.

Original languageEnglish
JournalNeuroscience Research
DOIs
Publication statusAccepted/In press - 2017

Fingerprint

Optogenetics
Dopamine D1 Receptors
Substantia Nigra
Rodentia
Pharmacology
Pars Reticulata

Keywords

  • Autistic spectrum disorder (ASD)
  • D1-MSNs
  • Direct pathway
  • Obsessive-compulsive spectrum disorders (OCSD)
  • Optogenetics
  • Repetitive behaviors
  • Striato-nigral pathway
  • Tourette syndrom

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Bouchekioua, Y., Tsutsui-Kimura, I., Sano, H., Koizumi, M., Tanaka, K. F., Yoshida, K., ... Mimura, M. (Accepted/In press). Striatonigral direct pathway activation is sufficient to induce repetitive behaviors. Neuroscience Research. https://doi.org/10.1016/j.neures.2017.09.007

Striatonigral direct pathway activation is sufficient to induce repetitive behaviors. / Bouchekioua, Youcef; Tsutsui-Kimura, Iku; Sano, Hiromi; Koizumi, Miwako; Tanaka, Kenji F.; Yoshida, Keitaro; Kosaki, Yutaka; Watanabe, Shigeru; Mimura, Masaru.

In: Neuroscience Research, 2017.

Research output: Contribution to journalArticle

Bouchekioua, Y, Tsutsui-Kimura, I, Sano, H, Koizumi, M, Tanaka, KF, Yoshida, K, Kosaki, Y, Watanabe, S & Mimura, M 2017, 'Striatonigral direct pathway activation is sufficient to induce repetitive behaviors', Neuroscience Research. https://doi.org/10.1016/j.neures.2017.09.007
Bouchekioua, Youcef ; Tsutsui-Kimura, Iku ; Sano, Hiromi ; Koizumi, Miwako ; Tanaka, Kenji F. ; Yoshida, Keitaro ; Kosaki, Yutaka ; Watanabe, Shigeru ; Mimura, Masaru. / Striatonigral direct pathway activation is sufficient to induce repetitive behaviors. In: Neuroscience Research. 2017.
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