Strong influence of dietary intake and physical activity on body fatness in elderly Japanese men

Age-associated loss of polygenic resistance against obesity

Kumpei Tanisawa, Tomoko Ito, Xiaomin Sun, Ryuken Ise, Satomi Oshima, Zhen Bo Cao, Shizuo Sakamoto, Masashi Tanaka, Mitsuru Higuchi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Genome-wide association studies identified single nucleotide polymorphisms (SNPs) associated with body mass index (BMI) in middle-aged populations; however, it is unclear whether these SNPs are associated with body fatness in elderly people. We examined the association between genetic risk score (GRS) from BMI-associated SNPs and body fatness in elderly Japanese men. We also examined the contribution of GRS, dietary macronutrient intake, and physical activity to body fatness by different age groups. GRS was calculated from 10 BMI-associated SNPs in 84 middle-aged (30-64 years) and 97 elderly (65-79 years) Japanese men; subjects were divided into low, middle, and high GRS groups. Dietary macronutrient intake was assessed using a questionnaire, and physical activity was evaluated using both a questionnaire and an accelerometer. The middle-aged individuals with a high GRS had greater BMI; waist circumference; and total abdominal fat, visceral fat, and subcutaneous fat areas than the middle-aged individuals with low GRS, whereas the indicators were not different between the GRS groups in elderly individuals. Multiple linear regression analysis showed that GRS was the strongest predictor of BMI, total abdominal fat, and visceral fat in the middle-aged group, whereas fat, alcohol, and protein intakes or vigorous-intensity physical activity were more strongly associated with these indicators than was GRS in the elderly group. These results suggest that GRS from BMI-associated SNPs is not predictive of body fatness in elderly Japanese men. The stronger contribution of dietary macronutrient intake and physical activity to body fatness may attenuate the genetic predisposition in elderly men.

Original languageEnglish
Article number416
JournalGenes and Nutrition
Volume9
Issue number5
DOIs
Publication statusPublished - 2014

Fingerprint

Obesity
Exercise
Body Mass Index
Single Nucleotide Polymorphism
Abdominal Fat
Intra-Abdominal Fat
Genome-Wide Association Study
Subcutaneous Fat
Waist Circumference
Genetic Predisposition to Disease
Linear Models
Age Groups
Fats
Regression Analysis
Alcohols
Population
Proteins

Keywords

  • Aging
  • Body fatness
  • Dietary macronutrient intake
  • Genetic risk score
  • Physical activity
  • SNP

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Genetics

Cite this

Strong influence of dietary intake and physical activity on body fatness in elderly Japanese men : Age-associated loss of polygenic resistance against obesity. / Tanisawa, Kumpei; Ito, Tomoko; Sun, Xiaomin; Ise, Ryuken; Oshima, Satomi; Cao, Zhen Bo; Sakamoto, Shizuo; Tanaka, Masashi; Higuchi, Mitsuru.

In: Genes and Nutrition, Vol. 9, No. 5, 416, 2014.

Research output: Contribution to journalArticle

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