Structural and biological assessment of zinc doped hydroxyapatite nanoparticles

Cristina Liana Popa, Aurélien Deniaud, Isabelle Michaud-Soret, Regis Guegan, Mikael Motelica-Heino, Daniela Predoi

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The aim of the current research work was to study the physicochemical and biological properties of synthesized zinc doped hydroxyapatite (ZnHAp) nanoparticles with Zn concentrations xZn = 0 (HAp), xZn = 0.07 (7ZnHAp), and xZn = 0.1 (10ZnHAp) for potential use in biological applications. The morphology, size, compositions, and incorporation of zinc into hydroxyapatite were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier Transform Infrared Spectroscopy (FTIR), Raman scattering, and X-Ray Photoelectron Spectroscopy (XPS). In addition, the cytotoxicity of ZnHAp nanoparticles was tested on both E. coli bacteria and human hepatocarcinoma cell line HepG2. The results showed that ZnHAp nanoparticles (HAp, 7ZnHAp, and 10ZnHAp) have slightly elongated morphologies with average diameters between 25 nm and 18 nm. On the other hand, a uniform and homogeneous distribution of the constituent elements (calcium, phosphorus, zinc, and oxygen) in the ZnHAp powder was noticed. Besides, FTIR and Raman analyses confirmed the proper hydroxyapatite structure of the synthesized ZnHAp nanoparticles with the signature of phosphate, carbonate, and hydroxyl groups. Moreover, it can be concluded that Zn doping at the tested concentrations is not inducing a specific prokaryote or eukaryote toxicity in HAp compounds.

Original languageEnglish
Article number1062878
JournalJournal of Nanomaterials
Volume2016
DOIs
Publication statusPublished - 2016 Jan 1
Externally publishedYes

Fingerprint

Durapatite
Hydroxyapatite
Zinc
Nanoparticles
Fourier transform infrared spectroscopy
Carbonates
Cytotoxicity
Chemical elements
Hydroxyl Radical
Powders
Phosphorus
Escherichia coli
Toxicity
Raman scattering
Calcium
Bacteria
Phosphates
X ray photoelectron spectroscopy
Cells
Doping (additives)

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Popa, C. L., Deniaud, A., Michaud-Soret, I., Guegan, R., Motelica-Heino, M., & Predoi, D. (2016). Structural and biological assessment of zinc doped hydroxyapatite nanoparticles. Journal of Nanomaterials, 2016, [1062878]. https://doi.org/10.1155/2016/1062878

Structural and biological assessment of zinc doped hydroxyapatite nanoparticles. / Popa, Cristina Liana; Deniaud, Aurélien; Michaud-Soret, Isabelle; Guegan, Regis; Motelica-Heino, Mikael; Predoi, Daniela.

In: Journal of Nanomaterials, Vol. 2016, 1062878, 01.01.2016.

Research output: Contribution to journalArticle

Popa, CL, Deniaud, A, Michaud-Soret, I, Guegan, R, Motelica-Heino, M & Predoi, D 2016, 'Structural and biological assessment of zinc doped hydroxyapatite nanoparticles', Journal of Nanomaterials, vol. 2016, 1062878. https://doi.org/10.1155/2016/1062878
Popa, Cristina Liana ; Deniaud, Aurélien ; Michaud-Soret, Isabelle ; Guegan, Regis ; Motelica-Heino, Mikael ; Predoi, Daniela. / Structural and biological assessment of zinc doped hydroxyapatite nanoparticles. In: Journal of Nanomaterials. 2016 ; Vol. 2016.
@article{a20b5efbf31d48e9b7f7f2d45ba81d4b,
title = "Structural and biological assessment of zinc doped hydroxyapatite nanoparticles",
abstract = "The aim of the current research work was to study the physicochemical and biological properties of synthesized zinc doped hydroxyapatite (ZnHAp) nanoparticles with Zn concentrations xZn = 0 (HAp), xZn = 0.07 (7ZnHAp), and xZn = 0.1 (10ZnHAp) for potential use in biological applications. The morphology, size, compositions, and incorporation of zinc into hydroxyapatite were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier Transform Infrared Spectroscopy (FTIR), Raman scattering, and X-Ray Photoelectron Spectroscopy (XPS). In addition, the cytotoxicity of ZnHAp nanoparticles was tested on both E. coli bacteria and human hepatocarcinoma cell line HepG2. The results showed that ZnHAp nanoparticles (HAp, 7ZnHAp, and 10ZnHAp) have slightly elongated morphologies with average diameters between 25 nm and 18 nm. On the other hand, a uniform and homogeneous distribution of the constituent elements (calcium, phosphorus, zinc, and oxygen) in the ZnHAp powder was noticed. Besides, FTIR and Raman analyses confirmed the proper hydroxyapatite structure of the synthesized ZnHAp nanoparticles with the signature of phosphate, carbonate, and hydroxyl groups. Moreover, it can be concluded that Zn doping at the tested concentrations is not inducing a specific prokaryote or eukaryote toxicity in HAp compounds.",
author = "Popa, {Cristina Liana} and Aur{\'e}lien Deniaud and Isabelle Michaud-Soret and Regis Guegan and Mikael Motelica-Heino and Daniela Predoi",
year = "2016",
month = "1",
day = "1",
doi = "10.1155/2016/1062878",
language = "English",
volume = "2016",
journal = "Journal of Nanomaterials",
issn = "1687-4110",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Structural and biological assessment of zinc doped hydroxyapatite nanoparticles

AU - Popa, Cristina Liana

AU - Deniaud, Aurélien

AU - Michaud-Soret, Isabelle

AU - Guegan, Regis

AU - Motelica-Heino, Mikael

AU - Predoi, Daniela

PY - 2016/1/1

Y1 - 2016/1/1

N2 - The aim of the current research work was to study the physicochemical and biological properties of synthesized zinc doped hydroxyapatite (ZnHAp) nanoparticles with Zn concentrations xZn = 0 (HAp), xZn = 0.07 (7ZnHAp), and xZn = 0.1 (10ZnHAp) for potential use in biological applications. The morphology, size, compositions, and incorporation of zinc into hydroxyapatite were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier Transform Infrared Spectroscopy (FTIR), Raman scattering, and X-Ray Photoelectron Spectroscopy (XPS). In addition, the cytotoxicity of ZnHAp nanoparticles was tested on both E. coli bacteria and human hepatocarcinoma cell line HepG2. The results showed that ZnHAp nanoparticles (HAp, 7ZnHAp, and 10ZnHAp) have slightly elongated morphologies with average diameters between 25 nm and 18 nm. On the other hand, a uniform and homogeneous distribution of the constituent elements (calcium, phosphorus, zinc, and oxygen) in the ZnHAp powder was noticed. Besides, FTIR and Raman analyses confirmed the proper hydroxyapatite structure of the synthesized ZnHAp nanoparticles with the signature of phosphate, carbonate, and hydroxyl groups. Moreover, it can be concluded that Zn doping at the tested concentrations is not inducing a specific prokaryote or eukaryote toxicity in HAp compounds.

AB - The aim of the current research work was to study the physicochemical and biological properties of synthesized zinc doped hydroxyapatite (ZnHAp) nanoparticles with Zn concentrations xZn = 0 (HAp), xZn = 0.07 (7ZnHAp), and xZn = 0.1 (10ZnHAp) for potential use in biological applications. The morphology, size, compositions, and incorporation of zinc into hydroxyapatite were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier Transform Infrared Spectroscopy (FTIR), Raman scattering, and X-Ray Photoelectron Spectroscopy (XPS). In addition, the cytotoxicity of ZnHAp nanoparticles was tested on both E. coli bacteria and human hepatocarcinoma cell line HepG2. The results showed that ZnHAp nanoparticles (HAp, 7ZnHAp, and 10ZnHAp) have slightly elongated morphologies with average diameters between 25 nm and 18 nm. On the other hand, a uniform and homogeneous distribution of the constituent elements (calcium, phosphorus, zinc, and oxygen) in the ZnHAp powder was noticed. Besides, FTIR and Raman analyses confirmed the proper hydroxyapatite structure of the synthesized ZnHAp nanoparticles with the signature of phosphate, carbonate, and hydroxyl groups. Moreover, it can be concluded that Zn doping at the tested concentrations is not inducing a specific prokaryote or eukaryote toxicity in HAp compounds.

UR - http://www.scopus.com/inward/record.url?scp=84982843288&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84982843288&partnerID=8YFLogxK

U2 - 10.1155/2016/1062878

DO - 10.1155/2016/1062878

M3 - Article

VL - 2016

JO - Journal of Nanomaterials

JF - Journal of Nanomaterials

SN - 1687-4110

M1 - 1062878

ER -