Structure-activity relationship of 9-methylstreptimidone, a compound that induces apoptosis selectively in adult T-cell leukemia cells

Masatoshi Takeiri, Eisuke Ota, Shigeru Nishiyama, Hiromasa Kiyota, Kazuo Umezawa

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We previously reported that 9-methylstreptimidone, a piperidine compound isolated from a culture filtrate of Streptomyces, induces apoptosis selectively in adult T-cell leukemia cells. It was screened for a compound that inhibits LPS-induced NF-κB and NO production in mouse macrophages. However, 9-methystreptimidone is poorly obtained from the producing microorganism and difficult to synthesize. Therefore, in the present research, we studied the structure-activity relationship to look for new selective inhibitors. We found that the structure of the unsaturated hydrophobic portion of 9-methylstreptimidone was essential for the inhibition of LPS-induced NO production. Among the 9-methylstreptimidone-related compounds tested, (±)-4,α-diepi-streptovitacin A inhibited NO production in macrophage-like cells as potently as 9-methylstreptimidone and without cellular toxicity. Moreover, this compound selectively induced apoptosis in adult T-cell leukemia MT-1 cells.

Original languageEnglish
Pages (from-to)7-14
Number of pages8
JournalOncology Research
Volume20
Issue number1
DOIs
Publication statusPublished - 2012 Sep 3
Externally publishedYes

Fingerprint

Adult T Cell Leukemia Lymphoma
Structure-Activity Relationship
Apoptosis
Macrophages
Streptomyces
9-methylstreptimidone
Research

Keywords

  • 9-Methylstreptimidone
  • Adult T-cell leukemia
  • Apoptosis
  • Macrophage
  • Streptovitacin

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Structure-activity relationship of 9-methylstreptimidone, a compound that induces apoptosis selectively in adult T-cell leukemia cells. / Takeiri, Masatoshi; Ota, Eisuke; Nishiyama, Shigeru; Kiyota, Hiromasa; Umezawa, Kazuo.

In: Oncology Research, Vol. 20, No. 1, 03.09.2012, p. 7-14.

Research output: Contribution to journalArticle

Takeiri, Masatoshi ; Ota, Eisuke ; Nishiyama, Shigeru ; Kiyota, Hiromasa ; Umezawa, Kazuo. / Structure-activity relationship of 9-methylstreptimidone, a compound that induces apoptosis selectively in adult T-cell leukemia cells. In: Oncology Research. 2012 ; Vol. 20, No. 1. pp. 7-14.
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