Structure and sequence of the mouse V1a and V1b vasopressin receptor genes

Shintaro Kikuchi, Akito Tanoue, Nobuhito Goda, Nobutake Matsuo, Gozoh Tsujimoto

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The structural organization and 5'-flanking region of the mouse V1a and V1b vasopressin receptor genes were determined. The mouse V1a receptor gene was located within an 8-kb XbaI fragment, and the mouse V1b receptor gene was located within a 14-kb EcoRV fragment. Both genes were comprised of two coding exons that were separated by a 2.3-kb and a 8.0-kb intron, respectively, located before the respective seventh transmembrane domain of the receptor sequence. The availability of these genes would allow us to study the functional role of V1a and V1b receptors by disrupting the gene in mice.

Original languageEnglish
Pages (from-to)388-392
Number of pages5
JournalJapanese Journal of Pharmacology
Volume81
Issue number4
DOIs
Publication statusPublished - 1999 Dec 1
Externally publishedYes

Keywords

  • V1a vasopressin receptor gene (mouse)
  • V1b vasopressin receptor gene (mouse)

ASJC Scopus subject areas

  • Pharmacology

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