Structure and solution properties of lipidheme-microsphere

T. Komatsu, Hiroyuki Nishide, E. Tsuchida

Research output: Contribution to journalArticle

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Abstract

Triglyceride microsphere emulsified with phospholipid derivative of heme (5,10,15,20-tetrakis[α,α,α,α-o-[2,2-dimethyl-20-[2-(trimethylammonioethoxy) phosphonatoxy]eicosanamido]phenyl]porphinatoiron(II); lipidheme) provides a totally synthetic artificial red cell (lipidheme-microsphere; LH-M). Its structure, solution properties and O2 binding ability are described. The particle diameter of the LH-M was ca. 90 nmφ elucidated by electron microscopy. Viscosity of the LH-M suspension (~1.5 cP) was much lower than that of human blood and the viscosity of mixed system of LH-M/human blood (1/1(v/v)) was 2.5 cP. Specific gravity, osmotic pressure, and colloid osmotic pressure of the LH-M suspension also satisfied the physiological needs. The LH-M can bind O2 reversibly in response to O2 pressure (P50(O2): 41 torr (pH 7.4, 37°C), O2 solubility of the LH-M was more than that of human blood caused by its high heme concentration.

Original languageEnglish
Pages (from-to)855-860
Number of pages6
JournalArtificial Cells, Blood Substitutes, and Immobilization Biotechnology
Volume22
Issue number3
Publication statusPublished - 1994

Fingerprint

Microspheres
Blood
Osmotic Pressure
Heme
Suspensions
Viscosity
Artificial Cells
Blood Viscosity
Specific Gravity
Phospholipids
Colloids
Density (specific gravity)
Solubility
Electron microscopy
Electron Microscopy
Triglycerides
Cells
Derivatives
Pressure

ASJC Scopus subject areas

  • Biotechnology
  • Biomedical Engineering
  • Biomaterials
  • Hematology

Cite this

Structure and solution properties of lipidheme-microsphere. / Komatsu, T.; Nishide, Hiroyuki; Tsuchida, E.

In: Artificial Cells, Blood Substitutes, and Immobilization Biotechnology, Vol. 22, No. 3, 1994, p. 855-860.

Research output: Contribution to journalArticle

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