Structure elucidation and enantioselective total synthesis of the potent HMG-CoA reductase inhibitor FR901512 via catalytic asymmetric Nozaki-Hiyama reactions

Masahiro Inoue, Masahisa Nakada

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The structure elucidation and enantioselective total synthesis of the potent HMG-CoA reductase inhibitor FR901512 were accomplished. FR901512 was prepared in 15 steps from the commercially available 2-bromo-4-methylbenzaldehyde via FR901516 in 16.3% overall yield (89% average yield). The catalytic asymmetric Nozaki-Hiyama reactions developed by us proved their applicability and reliability through this work, enabling the concise, efficient, and protecting-group-free enantioselective total syntheses of these new statins.

Original languageEnglish
Pages (from-to)4164-4165
Number of pages2
JournalJournal of the American Chemical Society
Volume129
Issue number14
DOIs
Publication statusPublished - 2007 Apr 11

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ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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