Structure of RizA, an l-amino-acid ligase from Bacillus subtilis

Wataru Kagawa, Toshinobu Arai, Shun Ishikura, Kuniki Kino, Hitoshi Kurumizaka

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

RizA is an l-amino-acid ligase from Bacillus subtilis that participates in the biosynthesis of rhizocticin, an oligopeptide antibiotic. The substrate-free form of RizA has been crystallized and the structure was solved at 2.8 Å resolution. The amino-acid-binding site appears to be capable of accommodating multiple amino acids, consistent with previous biochemical studies.

Original languageEnglish
Pages (from-to)1125-1130
Number of pages6
JournalActa Crystallographica Section:F Structural Biology Communications
Volume71
DOIs
Publication statusPublished - 2015 Sep 1

Keywords

  • ATP-grasp fold
  • dipeptide synthesis
  • l-amino-acid ligase
  • rhizocticin

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Genetics
  • Condensed Matter Physics

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