Structure of RizA, an l-amino-acid ligase from Bacillus subtilis

Wataru Kagawa, Toshinobu Arai, Shun Ishikura, Kuniki Kino, Hitoshi Kurumizaka

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    5 Citations (Scopus)


    RizA is an l-amino-acid ligase from Bacillus subtilis that participates in the biosynthesis of rhizocticin, an oligopeptide antibiotic. The substrate-free form of RizA has been crystallized and the structure was solved at 2.8 Å resolution. The amino-acid-binding site appears to be capable of accommodating multiple amino acids, consistent with previous biochemical studies.

    Original languageEnglish
    Pages (from-to)1125-1130
    Number of pages6
    JournalActa Crystallographica Section F:Structural Biology Communications
    Publication statusPublished - 2015 Sep 1



    • ATP-grasp fold
    • dipeptide synthesis
    • l-amino-acid ligase
    • rhizocticin

    ASJC Scopus subject areas

    • Biophysics
    • Genetics
    • Structural Biology
    • Condensed Matter Physics
    • Biochemistry

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