Studies into asymmetric catalysis of the Nozaki-Hiyama allenylation

Masahiro Inoue, Masahisa Nakada

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    Abstract

    (Chemical Equation Presented) From aldehydes to allenic alcohols: Studies into the asymmetric catalysis of the Nozaki-Hiyama allenylation are described. Ligand 1a is effective for the enantioselective allenylations of various aldehydes, with the generation of products with ee values ranging from 72-83%. The products can be easily desilylated or used as allenylsilanes. DIPEA = diisopropylethylamine, DMI = 1,3-dimethyl-2-imidazolidinone, DMS = dimethylsilyl, TMS = trimethylsilyl.

    Original languageEnglish
    Pages (from-to)252-255
    Number of pages4
    JournalAngewandte Chemie - International Edition
    Volume45
    Issue number2
    DOIs
    Publication statusPublished - 2005 Dec 23

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    Keywords

    • Allenes
    • Allenic alcohols
    • Asymmetric catalysis
    • Chromium
    • Enantioselectivity

    ASJC Scopus subject areas

    • Chemistry(all)

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