Studies into asymmetric catalysis of the Nozaki-Hiyama allenylation

Masahiro Inoue, Masahisa Nakada

Research output: Contribution to journalArticlepeer-review

57 Citations (Scopus)

Abstract

(Chemical Equation Presented) From aldehydes to allenic alcohols: Studies into the asymmetric catalysis of the Nozaki-Hiyama allenylation are described. Ligand 1a is effective for the enantioselective allenylations of various aldehydes, with the generation of products with ee values ranging from 72-83%. The products can be easily desilylated or used as allenylsilanes. DIPEA = diisopropylethylamine, DMI = 1,3-dimethyl-2-imidazolidinone, DMS = dimethylsilyl, TMS = trimethylsilyl.

Original languageEnglish
Pages (from-to)252-255
Number of pages4
JournalAngewandte Chemie - International Edition
Volume45
Issue number2
DOIs
Publication statusPublished - 2005 Dec 23

Keywords

  • Allenes
  • Allenic alcohols
  • Asymmetric catalysis
  • Chromium
  • Enantioselectivity

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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