Study of the 'Raman spectroscopic signature of life' in mitochondria isolated from budding yeast

Liang da Chiu, Masahiro Ando, Hiro o. Hamaguchi

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21 Citations (Scopus)


The 'Raman spectroscopic signature of life' is a Raman band at 1602 cm-1 that sharply reflects the metabolic activity of cell mitochondria. Here we report the study of thissignature in isolated yeast mitochondria. The existence and behaviour of the 1602 cm-1 band in isolated mitochondria have been confirmed to be the same as in living yeast cells: the intensity of the band decreases with timewhen a respiration inhibitor, sodium azide, is added. The present study shows the significance of isolated mitochondria in elucidating the origin of this still unassigned Raman band.

Original languageEnglish
Pages (from-to)2-3
Number of pages2
JournalJournal of Raman Spectroscopy
Issue number1
Publication statusPublished - 2010 Jan
Externally publishedYes



  • Budding yeast
  • Metabolic activity
  • Mitochondria
  • Raman spectroscopic signature of life
  • Respiration inhibition

ASJC Scopus subject areas

  • Spectroscopy
  • Materials Science(all)

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