Sub-threshold periodic stimulation can improve detection of weak neuronal signals

Minato Kawaguchi, Hiroyuki Mino, Keiko Momose, Dominique M. Durand

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Deep brain stimulation (DBS) is a technology designed to treat some neural disorders and abnormal neuronal activity such as Parkinson's disease. However, it has not been clear how periodic electrical stimuli can reduce the symptoms. The objective of this study is to test the hypothesis that the periodic signals can enhance endogenous signals in the network through stochastic resonance in a physiologically realistic neuron model of the central nervous system. In the computer simulations, two kinds of periodic waveforms were applied as extracellular sub-threshold electric stimuli, while the peak-to-baseline ratio (PBR) calculated from the power spectra of transmembrane potentials at the soma was used to quantify the detection of weak signals. It was shown that the PBR was increased, maximized, and then decreased as the frequency the periodic pulsatile stimuli increased, implying a resonance phenomenon depending on the frequency. It was concluded that the periodic electric stimuli utilized for DBS could play a key role in improving detection of weak signals when the amplitude and frequency of electric stimuli are appropriately set. Moreover, these results suggests a novel phenomenon for frequency dependent stochastic resonance capable of enhancing signals at specific frequencies.

    Original languageEnglish
    Title of host publication2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011
    Pages237-240
    Number of pages4
    DOIs
    Publication statusPublished - 2011
    Event2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011 - Cancun
    Duration: 2011 Apr 272011 May 1

    Other

    Other2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011
    CityCancun
    Period11/4/2711/5/1

    Fingerprint

    Deep Brain Stimulation
    Carisoprodol
    Computer Simulation
    Membrane Potentials
    Parkinson Disease
    Central Nervous System
    Technology
    Neurons

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Kawaguchi, M., Mino, H., Momose, K., & Durand, D. M. (2011). Sub-threshold periodic stimulation can improve detection of weak neuronal signals. In 2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011 (pp. 237-240). [5910531] https://doi.org/10.1109/NER.2011.5910531

    Sub-threshold periodic stimulation can improve detection of weak neuronal signals. / Kawaguchi, Minato; Mino, Hiroyuki; Momose, Keiko; Durand, Dominique M.

    2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011. 2011. p. 237-240 5910531.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Kawaguchi, M, Mino, H, Momose, K & Durand, DM 2011, Sub-threshold periodic stimulation can improve detection of weak neuronal signals. in 2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011., 5910531, pp. 237-240, 2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011, Cancun, 11/4/27. https://doi.org/10.1109/NER.2011.5910531
    Kawaguchi M, Mino H, Momose K, Durand DM. Sub-threshold periodic stimulation can improve detection of weak neuronal signals. In 2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011. 2011. p. 237-240. 5910531 https://doi.org/10.1109/NER.2011.5910531
    Kawaguchi, Minato ; Mino, Hiroyuki ; Momose, Keiko ; Durand, Dominique M. / Sub-threshold periodic stimulation can improve detection of weak neuronal signals. 2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011. 2011. pp. 237-240
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