Subacute effects of capsaicinoids on the distribution of white blood cells in rats

Shoko Aritoshi; Shogo Sato; Mari Kumazawa; Takamasa Ban; Jun Tanihata; Kaoru Tachiyashiki; Kazuhiko Imaizumi

doi:10.1248/jhs.56.99

Subacute effects of capsaicinoids on the distribution of white blood cells in rats

Shoko Aritoshi, Shogo Sato, Mari Kumazawa, Takamasa Ban, Jun Tanihata, Kaoru Tachiyashiki, Kazuhiko Imaizumi^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

The subacute effects of dihydrocapsaincin (DHC) and capsaicin (CAP) (dose = 3mg/kg body weight per day for 10 days, subcutaueous) on the number and distribution of white blood cells (WBCs) were studied in male adult rats. The administration of DHC and CAP for 10 days decreased significantly the number of total WBCs, lymphocytes and monocyte, and increased significantly the number of the neutrophil and eosinophil without changing the number of basophil. The administration of DHC significantly decreased thymus weight and increased adrenal weight, showing that DHC induced thymus atrophy and adrenal hypertrophy. These results suggest that capsaicinoids induced the decrease of acquired immunity responses and these phenomena may have in part participated in capsaicinoids-induced stress-responses in rats.

Original language	English
Pages (from-to)	99-103
Number of pages	5
Journal	Journal of Health Science
Volume	56
Issue number	1
DOIs	https://doi.org/10.1248/jhs.56.99
Publication status	Published - 2010 Feb

Keywords

Capsaicin
Capsaicinoid
Dihydrocapsaicin
Lymphocyte
White blood cell

ASJC Scopus subject areas

Toxicology
Health, Toxicology and Mutagenesis

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10.1248/jhs.56.99

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title = "Subacute effects of capsaicinoids on the distribution of white blood cells in rats",

abstract = "The subacute effects of dihydrocapsaincin (DHC) and capsaicin (CAP) (dose = 3mg/kg body weight per day for 10 days, subcutaueous) on the number and distribution of white blood cells (WBCs) were studied in male adult rats. The administration of DHC and CAP for 10 days decreased significantly the number of total WBCs, lymphocytes and monocyte, and increased significantly the number of the neutrophil and eosinophil without changing the number of basophil. The administration of DHC significantly decreased thymus weight and increased adrenal weight, showing that DHC induced thymus atrophy and adrenal hypertrophy. These results suggest that capsaicinoids induced the decrease of acquired immunity responses and these phenomena may have in part participated in capsaicinoids-induced stress-responses in rats.",

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AU - Aritoshi, Shoko

AU - Sato, Shogo

AU - Kumazawa, Mari

AU - Ban, Takamasa

AU - Tanihata, Jun

AU - Tachiyashiki, Kaoru

AU - Imaizumi, Kazuhiko

PY - 2010/2

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KW - Capsaicin

KW - Capsaicinoid

KW - Dihydrocapsaicin

KW - Lymphocyte

KW - White blood cell

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Subacute effects of capsaicinoids on the distribution of white blood cells in rats

Abstract

Keywords

ASJC Scopus subject areas

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