Sugar-Derived Poly(β-thioester)s as a Biomedical Scaffold

Nicholas G. Moon, Fiorella Mazzini, Allison M. Pekkanen, Emily M. Wilts, Timothy Edward Long

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The monomer isosorbide diacrylate (iSDA) and commercially available dithiols allowed access to a range of biosourced, degradable polymers. Altering the dithiol identity significantly affected the glass transition Tgs of the polymer products; however, polymers did not exhibit Tgs above room temperature. Incorporating the comonomer N,N'-methylene bisacrylamide provided mechanical reinforcement through hydrogen bonding, resulting in soft, pliable materials. Differential scannin calorimetry (DSC) and variable-temperature fourier-transform infrared (FTIR) spectroscopy indicated that increases in mechanical integrity resulted from hydrogen bonding. Dynamic mechanical analysis (DMA) revealed materials that exhibited suitable moduli and service windows at body temperature. Biological evaluation demonstrated favorable cytotoxicity and cell attachment, rendering these materials potential candidates as novel scaffold materials for tissue growth.

Original languageEnglish
JournalMacromolecular Chemistry and Physics
DOIs
Publication statusAccepted/In press - 2018 Jan 1
Externally publishedYes

Fingerprint

sugars
Scaffolds
Sugars
thiols
Polymers
polymers
body temperature
Hydrogen bonds
Isosorbide
hydrogen
reinforcement
methylene
integrity
attachment
Calorimetry
Dynamic mechanical analysis
heat measurement
Cytotoxicity
monomers
infrared spectroscopy

Keywords

  • Biomaterial
  • Isosorbide
  • Poly(β-thioester)
  • Renewable feedstock
  • Thiol-michael

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Physical and Theoretical Chemistry
  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry

Cite this

Moon, N. G., Mazzini, F., Pekkanen, A. M., Wilts, E. M., & Long, T. E. (Accepted/In press). Sugar-Derived Poly(β-thioester)s as a Biomedical Scaffold. Macromolecular Chemistry and Physics. https://doi.org/10.1002/macp.201800177

Sugar-Derived Poly(β-thioester)s as a Biomedical Scaffold. / Moon, Nicholas G.; Mazzini, Fiorella; Pekkanen, Allison M.; Wilts, Emily M.; Long, Timothy Edward.

In: Macromolecular Chemistry and Physics, 01.01.2018.

Research output: Contribution to journalArticle

Moon, Nicholas G. ; Mazzini, Fiorella ; Pekkanen, Allison M. ; Wilts, Emily M. ; Long, Timothy Edward. / Sugar-Derived Poly(β-thioester)s as a Biomedical Scaffold. In: Macromolecular Chemistry and Physics. 2018.
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