1H-MRS of intracranial meningiomas: What it can add to known clinical and MRI predictors of the histopathological and biological characteristics of the tumor?

Mikhail F. Chernov, Hidetoshi Kasuya, Kotaro Nakaya, Koichi Kato, Yuko Ono, Shigetoshi Yoshida, Yoshihiro Muragaki, Takashi Suzuki, Hiroshi Iseki, Osami Kubo, Tomokatsu Hori, Yoshikazu Okada, Kintomo Takakura

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    Abstract

    Objective: The main goal of the present study was evaluation of proton magnetic resonance spectroscopy (1H-MRS) in diagnosis of histopathologically aggressive intracranial meningiomas. Methods: Single-voxel 1H-MRS of 100 intracranial meningiomas was performed before their surgical resection. Investigated metabolites included mobile lipids, lactate, alanine, N-acetylaspartate (NAA), and choline-containing compounds (Cho). According to criteria of World Health Organization (WHO) 82 meningiomas were assigned histopathological grade I, 11 grade II, and 7 grade III. The MIB-1 index varied from 0% to 27.3% (median, 1.6%). In 43 cases tight adhesion of the tumor to the pia mater or brain tissue was macroscopically identified at surgery. The consistency of 49 meningiomas was characterized as soft, 26 as hard, and 25 as mixed. Results: No one metabolic parameter had statistically significant association with histopathological grade and subtype, invasive growth, and consistency of meningioma. Univariate statistical analysis revealed greater 1H-MRS-detected Cho content (P = 0.0444) and lower normalized NAA/Cho ratio (P = 0.0203) in tumors with MIB-1 index 5% and more. However, both parameters lost their statistical significance during evaluation in the multivariate model along with other clinical and radiological variables. It was revealed that non-benign histopathology of meningioma (WHO grade II/III) is mainly predicted by irregular shape (P = 0.0076) and large size (P = 0.0316), increased proliferative activity by irregular shape (P = 0.0056), and macroscopically invasive growth by prominent peritumoral edema (P = 0.0021). Conclusion: While 1H-MRS may be potentially used for the identification of meningiomas with high proliferative activity, it, seemingly, could not add substantial diagnostic information to other radiological predictors of malignancy in these tumors.

    Original languageEnglish
    Pages (from-to)202-212
    Number of pages11
    JournalClinical Neurology and Neurosurgery
    Volume113
    Issue number3
    DOIs
    Publication statusPublished - 2011 Apr 1

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    Keywords

    • Consistency
    • Histopathological grade
    • Histopathological subtype
    • Invasiveness
    • MIB-1 index
    • Meningioma
    • Proton magnetic resonance spectroscopy

    ASJC Scopus subject areas

    • Surgery
    • Clinical Neurology

    Cite this

    Chernov, M. F., Kasuya, H., Nakaya, K., Kato, K., Ono, Y., Yoshida, S., Muragaki, Y., Suzuki, T., Iseki, H., Kubo, O., Hori, T., Okada, Y., & Takakura, K. (2011). 1H-MRS of intracranial meningiomas: What it can add to known clinical and MRI predictors of the histopathological and biological characteristics of the tumor? Clinical Neurology and Neurosurgery, 113(3), 202-212. https://doi.org/10.1016/j.clineuro.2010.11.008