Superoxide dismutase and catalase in skeletal muscle: Adaptive response to exercise

Mitsuru Higuchi, L. J. Cartier, M. Chen, J. O. Holloszy

Research output: Contribution to journalArticle

208 Citations (Scopus)

Abstract

Cellular damage caused by free radical reactions may play a role in the aging process. A bout of exercise can increase free radical concentration with damage to mitochondria in muscle (Davies et al., 1982). This study was undertaken to determine if muscle adapts to exercise training with an enhancement of enzymatic defenses against free radical damage. A program of running that induced two-fold increases in mitochondrial enzymes in leg muscles of rats resulted in no increase in catalase or cytoplasmic superoxide dismutase (SOD) activities. Mitochondrial SOD activity was increased 37% in fast-twitch red and slow-twitch red types of muscle and 14% in white muscle. Thus, despite an increase in mitochondrial SOD, the ratio of SOD to mitochondrial citrate cycle and respiratory chain enzymes was decreased. It seems unlikely that increased capacity for enzymatic scavenging of superoxide radical is a major protective adaptation against free radical damage in exercise-trained muscle.

Original languageEnglish
Pages (from-to)281-286
Number of pages6
JournalJournals of Gerontology
Volume40
Issue number3
Publication statusPublished - 1985
Externally publishedYes

Fingerprint

Catalase
Superoxide Dismutase
Skeletal Muscle
Free Radicals
Muscles
Muscle Mitochondrion
Enzymes
Electron Transport
Citric Acid
Superoxides
Running
Leg
Exercise

ASJC Scopus subject areas

  • Ageing

Cite this

Higuchi, M., Cartier, L. J., Chen, M., & Holloszy, J. O. (1985). Superoxide dismutase and catalase in skeletal muscle: Adaptive response to exercise. Journals of Gerontology, 40(3), 281-286.

Superoxide dismutase and catalase in skeletal muscle : Adaptive response to exercise. / Higuchi, Mitsuru; Cartier, L. J.; Chen, M.; Holloszy, J. O.

In: Journals of Gerontology, Vol. 40, No. 3, 1985, p. 281-286.

Research output: Contribution to journalArticle

Higuchi, M, Cartier, LJ, Chen, M & Holloszy, JO 1985, 'Superoxide dismutase and catalase in skeletal muscle: Adaptive response to exercise', Journals of Gerontology, vol. 40, no. 3, pp. 281-286.
Higuchi, Mitsuru ; Cartier, L. J. ; Chen, M. ; Holloszy, J. O. / Superoxide dismutase and catalase in skeletal muscle : Adaptive response to exercise. In: Journals of Gerontology. 1985 ; Vol. 40, No. 3. pp. 281-286.
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