Support mechanism of a newly-designed mechanical artificial myocardium using shape memory alloy fibres

Yasuyuki Shiraishi, T. Yambe, S. Itoh, R. Sakata, Y. Wada, K. Sekine, Y. Saijo, S. Konno, S. Nitta, Q. Wang, H. Liu, M. Higa, Y. Luo, D. Ogawa, A. Tanaka, M. Yoshizawa, Y. Kakubari, H. Miura, F. Sato, H. MatsukiM. Uematsu, Y. Park, T. Tanaka, Mitsuo Umezu, T. Fujimoto, N. Masumoto, Y. Hori, H. Sasada, K. Tabayashi, E. Okamoto, D. Homma

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    As the heart failure is caused by the decrease in the myocardial contraction, the direct mechanical myocardial assistance in response to physiological demand, that is, the synchronous support of the contractile function from outside of the heart, might be effective. The purpose of this study was to develop an artificial myocardium which was capable of supporting the cardiac contraction directly by using the shape memory alloy fibres based on nanotechnology. Some methodologies using novel devices other than the artificial hearts are proposed so far with severe heart disease. However, it was also anticipated that the decrease in cardiac functions owing to the diastolic disability might be caused by using those ‘static’ devices. Then, this study was focused on an artificial myocardium using shape memory alloy fibres with a diameter of 100 – 150 um, and the authors examined its mechanism in a mock circulatory system as well as in animal experiments using goats. Basic characteristics of the material were evaluated prior to the hydrodynamic or hemodynamic examination using a mock ventricular model. The results were as follows: a) The length of the structure was able to be adjusted so that the system could wrap the whole heart effectively. b) In the hydrodynamic study using the mock circulatory system, the myocardial system was able to pump a flow against the afterload of arterial pressure level. c) In the animal experiments, aortic pressure and flow rate were elevated by 7 and 15% respectively by the mechanical assistance of the artificial myocardium, which was driven synchronising with the electrocardiogram, and also, d) The anatomically-identical shape of the artificial myocardium might be more effective for the assistance. In conclusion, it was indicated that this controllable artificial myocardial support system was effective for the mechanical cardiac support for the chronic heart failure.

    Original languageEnglish
    Title of host publicationIFMBE Proceedings
    PublisherSpringer Verlag
    Pages3161-3164
    Number of pages4
    Volume14
    Edition1
    Publication statusPublished - 2007
    Event10th World Congress on Medical Physics and Biomedical Engineering, WC 2006 - Seoul, Korea, Republic of
    Duration: 2006 Aug 272006 Sep 1

    Other

    Other10th World Congress on Medical Physics and Biomedical Engineering, WC 2006
    CountryKorea, Republic of
    CitySeoul
    Period06/8/2706/9/1

    Keywords

    • Artificial myocardium
    • Goat experiment
    • Hemodynamic effect
    • Mock ventricular model
    • Shape memory alloy fibre

    ASJC Scopus subject areas

    • Biomedical Engineering
    • Bioengineering

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  • Cite this

    Shiraishi, Y., Yambe, T., Itoh, S., Sakata, R., Wada, Y., Sekine, K., Saijo, Y., Konno, S., Nitta, S., Wang, Q., Liu, H., Higa, M., Luo, Y., Ogawa, D., Tanaka, A., Yoshizawa, M., Kakubari, Y., Miura, H., Sato, F., ... Homma, D. (2007). Support mechanism of a newly-designed mechanical artificial myocardium using shape memory alloy fibres. In IFMBE Proceedings (1 ed., Vol. 14, pp. 3161-3164). Springer Verlag.