Suppressing the formation of osteoclasts using bioactive components of the edible mushroom Leccinum extremiorientale (L. Vass.) singer (Agaricomycetideae)

Jae Hoon Choi, Nobuhiko Ozawa, Kikuko Masuda, Tomoyuki Koyama, Kazunaga Yazawa, Hirokazu Kawagishi

Research output: Contribution to journalArticle

5 Citations (Scopus)


Osteoporosis is a serious health problem for postmenopausal women and the elderly. We have focused our research on the bioactive substances from mushrooms to help cure osteoporosis by suppressing the formation of osteoclasts. In this study, two sterols were isolated from an edible mushroom Leccinum extremiorientale. The structures of 1 and 2 were identified by spectroscopic analysis. Compounds 1 and 2 showed the ability to suppress the formation of osteoclasts. This is the first report of the isolation of the compounds from the genus Leccinum and of the inhibitory activity of these compounds against the formation of osteoclasts.

Original languageEnglish
Pages (from-to)401-406
Number of pages6
JournalInternational Journal of Medicinal Mushrooms
Issue number4
Publication statusPublished - 2010
Externally publishedYes



  • Leccinum extremiorientale
  • Medicinal mushrooms
  • Osteoclast-formation
  • Sterol
  • Suppressing substance

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Drug Discovery
  • Pharmacology

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