Suppression of oral sweet taste sensation with Gymnema sylvestre affects postprandial gastrointestinal blood flow and gastric emptying in humans

Hideaki Kashima, Kohei Eguchi, Kanae Miyamoto, Masaki Fujimoto, Masako Yamaoka Endo, Nami Aso-Someya, Toshio Kobayashi, Naoyuki Hayashi, Yoshiyuki Fukuba

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

An oral sweet taste sensation (OSTS) exaggerates digestive activation transiently, but whether it has a role after swallowing a meal is not known. Gymnema sylvestre (GS) can inhibit the OSTS in humans. We explored the effect of the OSTS of glucose intake on gastrointestinal blood flow, gastric emptying, blood-glucose, and plasma-insulin responses during the postprandial phase. Eight participants ingested 200 g (50 g × 4 times) of 15% glucose solution containing 100 mg of 13C-sodium acetate after rinsing with 25 mL of 2.5% roasted green tea (control) or 2.5% GS solution. During each protocol, gastrointestinal blood flow and gastric emptying were measured by ultrasonography and 13C-sodium acetate breath test, respectively. Decreased subjective sweet taste intensity was observed in all participants in the GS group. The time to attain a peak value of blood flow in the celiac artery and gastric emptying were delayed in the GS group compared with the control group. At the initial phase after glucose intake, blood-glucose and plasma-insulin responses were lower in the GS group than those for the control group. These results suggest that the OSTS itself has a substantial role in controlling postprandial gastrointestinal activities, which may affect subsequent glycemic metabolism.

Original languageEnglish
Article numberbjw126
Pages (from-to)295-302
Number of pages8
JournalChemical Senses
Volume42
Issue number4
DOIs
Publication statusPublished - 2017 May 1
Externally publishedYes

Keywords

  • Cephalic phase
  • Gastric emptying
  • Gastrointestinal blood flow
  • Glycemic control
  • Oral sweet taste

ASJC Scopus subject areas

  • Physiology
  • Sensory Systems
  • Physiology (medical)
  • Behavioral Neuroscience

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