Suppressive effect of peach leaf extract on glucose absorption from the small intestine of mice

Miyuki Shirosaki, Tomoyuki Koyama, Kazunaga Yazawa

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The crude extract of peach leaves dose-dependently suppressed the postprandial elevation in the blood glucose level after an oral administration of soluble starch to mice. This study examines the mechanism for this suppressive effect in vivo. An oral carbohydrateloading test on mice showed that the peach leaf extract suppressed the glucose-induced increase in the blood level of glucose, but without affecting the insulin level. An enteral soluble starch and glucose loading test on mice also showed that the crude extract (1,000 mg/kg) significantly suppressed the postprandial elevation of the blood glucose level and increased the amount of glucose that remained in the intestine to within the same range as that with phloridzin (500 mg/kg), a natural sodium-dependent glucose transporter (SGLT)-specific inhibitor. In contrast, the extract did not suppress the postprandial elevation of the blood triglyceride and cholesterol levels in mice, and did not affect the normal blood glucose level in a feeding test for 21 d. These results reveal that the extract of peach leaves suppressed the postprandial elevation of blood glucose level by inhibiting the absorption of glucose in the small intestine of mice.

Original languageEnglish
Pages (from-to)89-94
Number of pages6
JournalBioscience, Biotechnology and Biochemistry
Volume76
Issue number1
DOIs
Publication statusPublished - 2012
Externally publishedYes

Keywords

  • Food for diabetes therapy
  • Glucose absorption
  • Peach leaf
  • Prunus persica Batsch

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Applied Microbiology and Biotechnology
  • Analytical Chemistry
  • Organic Chemistry

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