Supramolecular triblock copolymers containing complementary nucleobase molecular recognition

Brian D. Mather, Margaux B. Baker, Frederick L. Beyer, Michael A.G. Berg, Matthew D. Greeny, Timothy Edward Long

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Abstract

A novel difunctional alkoxyamine initiator, DEPN2, was synthesized and utilized as an efficient initiator in nitroxide-mediated controlled radical polymerization of triblock copolymers. Complementary hydrogen-bonding triblock copolymers containing adenine (A) and thymine (T) nucleobase-functionalized outer blocks were synthesized. These thermoplastic elastomeric block copolymers contained short nucleobase-functionalized outer blocks (Mn ∼ 1K-4K) and n-butyl acrylate rubber blocks of variable length (Mn ∼ 14K-70K). Hydrogen-bonding interactions were observed for blends of the complementary nucleobase-functionalized block copolymers in terms of increased specific viscosity as well as higher scaling exponents for specific viscosity as a function of solution concentration. In the solid state, the blends exhibited evidence of a complementary A-T hard phase, which formed upon annealing, and dynamic mechanical analysis (DMA) revealed higher softening temperatures. Morphological development of the block copolymers was studied using SAXS and AFM, which revealed intermediate interdomain spacings and surface textures for the blends compared to the individual precursors. Hydrogen-bonding interactions enabled the compatibilization of complementary hydrogen-bonding guest molecules such as 9-octyladenine.

Original languageEnglish
Pages (from-to)6834-6845
Number of pages12
JournalMacromolecules
Volume40
Issue number19
DOIs
Publication statusPublished - 2007 Sep 18
Externally publishedYes

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ASJC Scopus subject areas

  • Materials Chemistry

Cite this

Mather, B. D., Baker, M. B., Beyer, F. L., Berg, M. A. G., Greeny, M. D., & Long, T. E. (2007). Supramolecular triblock copolymers containing complementary nucleobase molecular recognition. Macromolecules, 40(19), 6834-6845. https://doi.org/10.1021/ma070865y