Surface-modified diamond field-effect transistors for enzyme-immobilized biosensors

Kwang Soup Song, Munenori Degawa, Yusuke Nakamura, Hirofumi Kanazawa, Hitoshi Umezawa, Hiroshi Kawarada

    Research output: Contribution to journalArticle

    53 Citations (Scopus)

    Abstract

    The enzyme sensors using electrolyte-solution-gate diamond field effect transistors (SGFETs) have been developed for the first time. The hydrogen-terminated surface channel of the FETs was modified into partially aminated and oxygen-terminated (H-A-O-terminated) with irradiation of ultraviolet in an ammonia environment. The pH response of that is obtained about 50 mV/pH at pH 2-10. The concentration of substrates (urea or glucose) in the electrolyte solution has been detected by the pH change due to the bio-catalyzed effect of enzyme (urease or glucose oxidase), which is immobilized on the channel of SGFETs. The sensitivity of urea and glucose is approximately 30 mV/decade and 20 mV/decade respectively.

    Original languageEnglish
    JournalJapanese Journal of Applied Physics, Part 2: Letters
    Volume43
    Issue number6 B
    Publication statusPublished - 2004 Jun 15

    Fingerprint

    Field effect transistors
    bioinstrumentation
    Biosensors
    enzymes
    Diamonds
    field effect transistors
    Enzymes
    diamonds
    glucose
    Urea
    Glucose
    Enzyme sensors
    ureas
    Electrolytes
    Glucose oxidase
    electrolytes
    Ammonia
    oxidase
    Irradiation
    ammonia

    Keywords

    • Diamond SGFETs
    • Enzyme
    • Glucose
    • H-A-O-terminated
    • Urea

    ASJC Scopus subject areas

    • Physics and Astronomy (miscellaneous)

    Cite this

    Surface-modified diamond field-effect transistors for enzyme-immobilized biosensors. / Song, Kwang Soup; Degawa, Munenori; Nakamura, Yusuke; Kanazawa, Hirofumi; Umezawa, Hitoshi; Kawarada, Hiroshi.

    In: Japanese Journal of Applied Physics, Part 2: Letters, Vol. 43, No. 6 B, 15.06.2004.

    Research output: Contribution to journalArticle

    Song, Kwang Soup ; Degawa, Munenori ; Nakamura, Yusuke ; Kanazawa, Hirofumi ; Umezawa, Hitoshi ; Kawarada, Hiroshi. / Surface-modified diamond field-effect transistors for enzyme-immobilized biosensors. In: Japanese Journal of Applied Physics, Part 2: Letters. 2004 ; Vol. 43, No. 6 B.
    @article{c70a869a9a264aee8e291da9d213d965,
    title = "Surface-modified diamond field-effect transistors for enzyme-immobilized biosensors",
    abstract = "The enzyme sensors using electrolyte-solution-gate diamond field effect transistors (SGFETs) have been developed for the first time. The hydrogen-terminated surface channel of the FETs was modified into partially aminated and oxygen-terminated (H-A-O-terminated) with irradiation of ultraviolet in an ammonia environment. The pH response of that is obtained about 50 mV/pH at pH 2-10. The concentration of substrates (urea or glucose) in the electrolyte solution has been detected by the pH change due to the bio-catalyzed effect of enzyme (urease or glucose oxidase), which is immobilized on the channel of SGFETs. The sensitivity of urea and glucose is approximately 30 mV/decade and 20 mV/decade respectively.",
    keywords = "Diamond SGFETs, Enzyme, Glucose, H-A-O-terminated, Urea",
    author = "Song, {Kwang Soup} and Munenori Degawa and Yusuke Nakamura and Hirofumi Kanazawa and Hitoshi Umezawa and Hiroshi Kawarada",
    year = "2004",
    month = "6",
    day = "15",
    language = "English",
    volume = "43",
    journal = "Japanese Journal of Applied Physics, Part 1: Regular Papers & Short Notes",
    issn = "0021-4922",
    publisher = "Japan Society of Applied Physics",
    number = "6 B",

    }

    TY - JOUR

    T1 - Surface-modified diamond field-effect transistors for enzyme-immobilized biosensors

    AU - Song, Kwang Soup

    AU - Degawa, Munenori

    AU - Nakamura, Yusuke

    AU - Kanazawa, Hirofumi

    AU - Umezawa, Hitoshi

    AU - Kawarada, Hiroshi

    PY - 2004/6/15

    Y1 - 2004/6/15

    N2 - The enzyme sensors using electrolyte-solution-gate diamond field effect transistors (SGFETs) have been developed for the first time. The hydrogen-terminated surface channel of the FETs was modified into partially aminated and oxygen-terminated (H-A-O-terminated) with irradiation of ultraviolet in an ammonia environment. The pH response of that is obtained about 50 mV/pH at pH 2-10. The concentration of substrates (urea or glucose) in the electrolyte solution has been detected by the pH change due to the bio-catalyzed effect of enzyme (urease or glucose oxidase), which is immobilized on the channel of SGFETs. The sensitivity of urea and glucose is approximately 30 mV/decade and 20 mV/decade respectively.

    AB - The enzyme sensors using electrolyte-solution-gate diamond field effect transistors (SGFETs) have been developed for the first time. The hydrogen-terminated surface channel of the FETs was modified into partially aminated and oxygen-terminated (H-A-O-terminated) with irradiation of ultraviolet in an ammonia environment. The pH response of that is obtained about 50 mV/pH at pH 2-10. The concentration of substrates (urea or glucose) in the electrolyte solution has been detected by the pH change due to the bio-catalyzed effect of enzyme (urease or glucose oxidase), which is immobilized on the channel of SGFETs. The sensitivity of urea and glucose is approximately 30 mV/decade and 20 mV/decade respectively.

    KW - Diamond SGFETs

    KW - Enzyme

    KW - Glucose

    KW - H-A-O-terminated

    KW - Urea

    UR - http://www.scopus.com/inward/record.url?scp=4243106113&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=4243106113&partnerID=8YFLogxK

    M3 - Article

    AN - SCOPUS:4243106113

    VL - 43

    JO - Japanese Journal of Applied Physics, Part 1: Regular Papers & Short Notes

    JF - Japanese Journal of Applied Physics, Part 1: Regular Papers & Short Notes

    SN - 0021-4922

    IS - 6 B

    ER -