Surgical timing prediction of patient-specific congenital tracheal stenosis with bridging bronchus by using computational aerodynamics

Juanya Shen, Limin Zhu, Zhirong Tong, Jinfen Liu, Mitsuo Umezu, Zhuomin Xu, Jinlong Liu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Congenital tracheal stenosis (CTS) has a high clinical mortality in neonates and infants. Although the procedure of slide tracheoplasty (STP) applied over the years, it is still a challenge for clinicians to predict the surgical timing of the CTS correction. In the present study, we studied on three-dimensional (3D) aerodynamic analysis of an original tracheal model from a specific patient with CTS and bridging bronchus (BB) and four new reconstructed models. We constructed a 3D patient-specific tracheal model based on CT images and applied computer-aided design (CAD) to reconstruct four models to imitate the stenosis development of CTS. Average pressure drop (APD), wall shear stress (WSS) and velocity streamlines were calculated to analyze local aerodynamic characteristics for the evaluation of airflow at the inspiration phase and expiration phase, respectively. We found APD, WSS and AEL decreased during the respiration with the decrease of stenosis. Three abnormal gradients in APD were observed between the main stenosis of trachea arrived at 80% and 60%. This implied the surgical correction may be required when the main stenosis reached 60%. The combination of CAD and aerodynamic analysis is a potential noninvasive tool for surgical timing prediction in the management of patient-specific correction of CTS.

Original languageEnglish
Title of host publicationAdvanced Computational Methods in Life System Modeling and Simulation - International Conference on Life System Modeling and Simulation, LSMS 2017 and International Conference on Intelligent Computing for Sustainable Energy and Environment, ICSEE 2017, Proceedings
EditorsMinrui Fei, Shiwei Ma, Xin Li, Xin Sun, Li Jia, Zhou Su
PublisherSpringer Verlag
Pages181-190
Number of pages10
ISBN (Print)9789811063695
DOIs
Publication statusPublished - 2017
EventInternational Conference on Life System Modeling and Simulation, LSMS 2017 and International Conference on Intelligent Computing for Sustainable Energy and Environment, ICSEE 2017 - Nanjing, China
Duration: 2017 Sep 222017 Sep 24

Publication series

NameCommunications in Computer and Information Science
Volume761
ISSN (Print)1865-0929

Other

OtherInternational Conference on Life System Modeling and Simulation, LSMS 2017 and International Conference on Intelligent Computing for Sustainable Energy and Environment, ICSEE 2017
CountryChina
CityNanjing
Period17/9/2217/9/24

Keywords

  • Aerodynamics
  • Airflow
  • Computational fluid dynamics
  • Computer-aided design
  • Congenital tracheal stenosis

ASJC Scopus subject areas

  • Computer Science(all)
  • Mathematics(all)

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