Surgical timing prediction of patient-specific congenital tracheal stenosis with bridging bronchus by using computational aerodynamics

Juanya Shen, Limin Zhu, Zhirong Tong, Jinfen Liu, Mitsuo Umezu, Zhuomin Xu, Jinlong Liu

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Congenital tracheal stenosis (CTS) has a high clinical mortality in neonates and infants. Although the procedure of slide tracheoplasty (STP) applied over the years, it is still a challenge for clinicians to predict the surgical timing of the CTS correction. In the present study, we studied on three-dimensional (3D) aerodynamic analysis of an original tracheal model from a specific patient with CTS and bridging bronchus (BB) and four new reconstructed models. We constructed a 3D patient-specific tracheal model based on CT images and applied computer-aided design (CAD) to reconstruct four models to imitate the stenosis development of CTS. Average pressure drop (APD), wall shear stress (WSS) and velocity streamlines were calculated to analyze local aerodynamic characteristics for the evaluation of airflow at the inspiration phase and expiration phase, respectively. We found APD, WSS and AEL decreased during the respiration with the decrease of stenosis. Three abnormal gradients in APD were observed between the main stenosis of trachea arrived at 80% and 60%. This implied the surgical correction may be required when the main stenosis reached 60%. The combination of CAD and aerodynamic analysis is a potential noninvasive tool for surgical timing prediction in the management of patient-specific correction of CTS.

    Original languageEnglish
    Title of host publicationAdvanced Computational Methods in Life System Modeling and Simulation - International Conference on Life System Modeling and Simulation, LSMS 2017 and International Conference on Intelligent Computing for Sustainable Energy and Environment, ICSEE 2017, Proceedings
    PublisherSpringer Verlag
    Pages181-190
    Number of pages10
    Volume761
    ISBN (Print)9789811063695
    DOIs
    Publication statusPublished - 2017
    EventInternational Conference on Life System Modeling and Simulation, LSMS 2017 and International Conference on Intelligent Computing for Sustainable Energy and Environment, ICSEE 2017 - Nanjing, China
    Duration: 2017 Sep 222017 Sep 24

    Publication series

    NameCommunications in Computer and Information Science
    Volume761
    ISSN (Print)1865-0929

    Other

    OtherInternational Conference on Life System Modeling and Simulation, LSMS 2017 and International Conference on Intelligent Computing for Sustainable Energy and Environment, ICSEE 2017
    CountryChina
    CityNanjing
    Period17/9/2217/9/24

    Fingerprint

    Stenosis
    Aerodynamics
    Timing
    Computational fluid dynamics
    Pressure drop
    Prediction
    Shear stress
    Computer aided design
    Pressure Drop
    Wall Shear Stress
    Computer-aided Design
    Aerodynamic Characteristics
    CT Image
    Respiration
    Streamlines
    Mortality
    Model
    Model-based
    Gradient
    Predict

    Keywords

    • Aerodynamics
    • Airflow
    • Computational fluid dynamics
    • Computer-aided design
    • Congenital tracheal stenosis

    ASJC Scopus subject areas

    • Computer Science(all)
    • Mathematics(all)

    Cite this

    Shen, J., Zhu, L., Tong, Z., Liu, J., Umezu, M., Xu, Z., & Liu, J. (2017). Surgical timing prediction of patient-specific congenital tracheal stenosis with bridging bronchus by using computational aerodynamics. In Advanced Computational Methods in Life System Modeling and Simulation - International Conference on Life System Modeling and Simulation, LSMS 2017 and International Conference on Intelligent Computing for Sustainable Energy and Environment, ICSEE 2017, Proceedings (Vol. 761, pp. 181-190). (Communications in Computer and Information Science; Vol. 761). Springer Verlag. https://doi.org/10.1007/978-981-10-6370-1_18

    Surgical timing prediction of patient-specific congenital tracheal stenosis with bridging bronchus by using computational aerodynamics. / Shen, Juanya; Zhu, Limin; Tong, Zhirong; Liu, Jinfen; Umezu, Mitsuo; Xu, Zhuomin; Liu, Jinlong.

    Advanced Computational Methods in Life System Modeling and Simulation - International Conference on Life System Modeling and Simulation, LSMS 2017 and International Conference on Intelligent Computing for Sustainable Energy and Environment, ICSEE 2017, Proceedings. Vol. 761 Springer Verlag, 2017. p. 181-190 (Communications in Computer and Information Science; Vol. 761).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Shen, J, Zhu, L, Tong, Z, Liu, J, Umezu, M, Xu, Z & Liu, J 2017, Surgical timing prediction of patient-specific congenital tracheal stenosis with bridging bronchus by using computational aerodynamics. in Advanced Computational Methods in Life System Modeling and Simulation - International Conference on Life System Modeling and Simulation, LSMS 2017 and International Conference on Intelligent Computing for Sustainable Energy and Environment, ICSEE 2017, Proceedings. vol. 761, Communications in Computer and Information Science, vol. 761, Springer Verlag, pp. 181-190, International Conference on Life System Modeling and Simulation, LSMS 2017 and International Conference on Intelligent Computing for Sustainable Energy and Environment, ICSEE 2017, Nanjing, China, 17/9/22. https://doi.org/10.1007/978-981-10-6370-1_18
    Shen J, Zhu L, Tong Z, Liu J, Umezu M, Xu Z et al. Surgical timing prediction of patient-specific congenital tracheal stenosis with bridging bronchus by using computational aerodynamics. In Advanced Computational Methods in Life System Modeling and Simulation - International Conference on Life System Modeling and Simulation, LSMS 2017 and International Conference on Intelligent Computing for Sustainable Energy and Environment, ICSEE 2017, Proceedings. Vol. 761. Springer Verlag. 2017. p. 181-190. (Communications in Computer and Information Science). https://doi.org/10.1007/978-981-10-6370-1_18
    Shen, Juanya ; Zhu, Limin ; Tong, Zhirong ; Liu, Jinfen ; Umezu, Mitsuo ; Xu, Zhuomin ; Liu, Jinlong. / Surgical timing prediction of patient-specific congenital tracheal stenosis with bridging bronchus by using computational aerodynamics. Advanced Computational Methods in Life System Modeling and Simulation - International Conference on Life System Modeling and Simulation, LSMS 2017 and International Conference on Intelligent Computing for Sustainable Energy and Environment, ICSEE 2017, Proceedings. Vol. 761 Springer Verlag, 2017. pp. 181-190 (Communications in Computer and Information Science).
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