Switching of the surface function of liposomes modified with poly(ethylene glycol)-lipids

Kohei Kubota, Yosuke Okamura, Shinji Takeoka

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Liposomes of which the surface was modified with poly(ethylene glycol) (PEG) chains are used to prevent aggregation and fusion and to prolong blood circulation. PEG-lipids were immobilized onto the surface of liposomes by simply adding their aqueous dispersions to the liposome dispersions. However, they dissociated from the liposomes by dilution of the mixed dispersions because they were incorporated into the liposomes in an equilibrium state. For the tight immobilization of the PEG-lipids with the long PEG chain onto the liposome surface, an increased number of alkyl chains is necessary.

    Original languageEnglish
    Title of host publicationPolymer Preprints, Japan
    Pages4939-4940
    Number of pages2
    Volume54
    Edition2
    Publication statusPublished - 2005
    Event54th SPSJ Symposium on Macromolecules - Yamagata
    Duration: 2005 Sep 202005 Sep 22

    Other

    Other54th SPSJ Symposium on Macromolecules
    CityYamagata
    Period05/9/2005/9/22

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    Keywords

    • Dissociation
    • Dodecapeptide
    • Hydrophilic-hydrophobic balance
    • Liposome
    • Multi alkyl chains
    • Poly(ethylene glycol)-lipid

    ASJC Scopus subject areas

    • Engineering(all)

    Cite this

    Kubota, K., Okamura, Y., & Takeoka, S. (2005). Switching of the surface function of liposomes modified with poly(ethylene glycol)-lipids. In Polymer Preprints, Japan (2 ed., Vol. 54, pp. 4939-4940)