Switching of the surface function of liposomes modified with poly(ethylene glycol)-lipids

Kohei Kubota*, Yosuke Okamura, Shinji Takeoka

*Corresponding author for this work

Research output: Contribution to conferencePaperpeer-review

Abstract

Liposomes of which the surface was modified with poly(ethylene glycol) (PEG) chains are used to prevent aggregation and fusion and to prolong blood circulation. PEG-lipids were immobilized onto the surface of liposomes by simply adding their aqueous dispersions to the liposome dispersions. However, they dissociated from the liposomes by dilution of the mixed dispersions because they were incorporated into the liposomes in an equilibrium state. For the tight immobilization of the PEG-lipids with the long PEG chain onto the liposome surface, an increased number of alkyl chains is necessary.

Original languageEnglish
Pages4939-4940
Number of pages2
Publication statusPublished - 2005 Dec 1
Event54th SPSJ Symposium on Macromolecules - Yamagata, Japan
Duration: 2005 Sep 202005 Sep 22

Other

Other54th SPSJ Symposium on Macromolecules
Country/TerritoryJapan
CityYamagata
Period05/9/2005/9/22

Keywords

  • Dissociation
  • Dodecapeptide
  • Hydrophilic-hydrophobic balance
  • Liposome
  • Multi alkyl chains
  • Poly(ethylene glycol)-lipid

ASJC Scopus subject areas

  • Engineering(all)

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