Syn-selective kobayashi aldol reaction using acetals

Hiroyuki Tsukada, Yuki Mukaeda, Seijiro Hosokawa

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The Kobayashi aldol reaction has been used to construct anti-aldol products by remote stereoinduction. Since the product of the Kobayashi aldol reaction has a typical polyketide structure, this reaction has been applied to the total synthesis of natural products. By varying this reaction, it was found that the reaction with acetals in the presence of Lewis acid proceeded to give syn adducts in high stereoselectivity. This is the first example of the stereoselective reaction of the chiral dienol ether and acetals.

Original languageEnglish
Pages (from-to)678-681
Number of pages4
JournalOrganic Letters
Volume15
Issue number3
DOIs
Publication statusPublished - 2013 Feb 1

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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