Syn-selective kobayashi aldol reaction using the E,E-vinylketene silyl N,O -acetal

Yuki Mukaeda, Takuya Kato, Seijiro Hosokawa

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    30 Citations (Scopus)

    Abstract

    The Kobayashi aldol reaction is one of the most powerful methods to synthesize the polyketide skeleton and has been applied to the total synthesis of natural products. This methodology has been used to construct anti-aldol products, and only a few precedents on the syn-selective Kobayashi aldol reaction are known. A syn-selective Kobayashi aldol reaction by using the E,E-vinylketene silyl N,O-acetal and an excess amount of Lewis acid is presented.

    Original languageEnglish
    Pages (from-to)5298-5301
    Number of pages4
    JournalOrganic Letters
    Volume14
    Issue number20
    DOIs
    Publication statusPublished - 2012 Oct 19

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    ASJC Scopus subject areas

    • Organic Chemistry
    • Physical and Theoretical Chemistry
    • Biochemistry

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