Medium size bicyclic ethers of 7-, 8-, and 9-membered rings were synthesized by connection between a hydroxy group on dihydropyranyl ring and a propargylic cation that was stabilized as an acetylene biscobalthexacarbonyl complex under acidic conditions. This cyclization selectively afforded the syntrans bicyclic ring system often seen in marine toxins such as ciguatoxin.
|Number of pages||2|
|Publication status||Published - 1996|
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