Synaptic transmission from subplate neurons controls radial migration of neocortical neurons

Chiaki Ohtaka-Maruyama, Mayumi Okamoto, Kentaro Endo, Minori Oshima, Noe Kaneko, Kei Yura, Haruo Okado, Takaki Miyata, Nobuaki Maeda

    Research output: Contribution to journalArticle

    21 Citations (Scopus)

    Abstract

    The neocortex exhibits a six-layered structure that is formed by radial migration of excitatory neurons, for which the multipolar-to-bipolar transition of immature migrating multipolar neurons is required. Here, we report that subplate neurons, one of the first neuron types born in the neocortex, manage the multipolar-to-bipolar transition of migrating neurons. By histochemical, imaging, and microarray analyses on the mouse embryonic cortex, we found that subplate neurons extend neurites toward the ventricular side of the subplate and form transient glutamatergic synapses on the multipolar neurons just below the subplate. NMDAR (N-methyl-D-aspartate receptor)-mediated synaptic transmission from subplate neurons to multipolar neurons induces themultipolar-to-bipolar transition, leading to a change inmigration mode from slow multipolar migration to faster radial glial-guided locomotion. Our data suggested that transient synapses formed on early immature neurons regulate radialmigration.

    Original languageEnglish
    Pages (from-to)313-317
    Number of pages5
    JournalScience
    Volume360
    Issue number6386
    DOIs
    Publication statusPublished - 2018 Apr 20

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    Synaptic Transmission
    Neurons
    Neocortex
    Synapses
    Neurites
    Locomotion
    Microarray Analysis
    N-Methyl-D-Aspartate Receptors
    Neuroglia

    ASJC Scopus subject areas

    • General

    Cite this

    Ohtaka-Maruyama, C., Okamoto, M., Endo, K., Oshima, M., Kaneko, N., Yura, K., ... Maeda, N. (2018). Synaptic transmission from subplate neurons controls radial migration of neocortical neurons. Science, 360(6386), 313-317. https://doi.org/10.1126/science.aar2866

    Synaptic transmission from subplate neurons controls radial migration of neocortical neurons. / Ohtaka-Maruyama, Chiaki; Okamoto, Mayumi; Endo, Kentaro; Oshima, Minori; Kaneko, Noe; Yura, Kei; Okado, Haruo; Miyata, Takaki; Maeda, Nobuaki.

    In: Science, Vol. 360, No. 6386, 20.04.2018, p. 313-317.

    Research output: Contribution to journalArticle

    Ohtaka-Maruyama, C, Okamoto, M, Endo, K, Oshima, M, Kaneko, N, Yura, K, Okado, H, Miyata, T & Maeda, N 2018, 'Synaptic transmission from subplate neurons controls radial migration of neocortical neurons', Science, vol. 360, no. 6386, pp. 313-317. https://doi.org/10.1126/science.aar2866
    Ohtaka-Maruyama C, Okamoto M, Endo K, Oshima M, Kaneko N, Yura K et al. Synaptic transmission from subplate neurons controls radial migration of neocortical neurons. Science. 2018 Apr 20;360(6386):313-317. https://doi.org/10.1126/science.aar2866
    Ohtaka-Maruyama, Chiaki ; Okamoto, Mayumi ; Endo, Kentaro ; Oshima, Minori ; Kaneko, Noe ; Yura, Kei ; Okado, Haruo ; Miyata, Takaki ; Maeda, Nobuaki. / Synaptic transmission from subplate neurons controls radial migration of neocortical neurons. In: Science. 2018 ; Vol. 360, No. 6386. pp. 313-317.
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