Synaptic transmission from subplate neurons controls radial migration of neocortical neurons

Chiaki Ohtaka-Maruyama, Mayumi Okamoto, Kentaro Endo, Minori Oshima, Noe Kaneko, Kei Yura, Haruo Okado, Takaki Miyata, Nobuaki Maeda

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The neocortex exhibits a six-layered structure that is formed by radial migration of excitatory neurons, for which the multipolar-to-bipolar transition of immature migrating multipolar neurons is required. Here, we report that subplate neurons, one of the first neuron types born in the neocortex, manage the multipolar-to-bipolar transition of migrating neurons. By histochemical, imaging, and microarray analyses on the mouse embryonic cortex, we found that subplate neurons extend neurites toward the ventricular side of the subplate and form transient glutamatergic synapses on the multipolar neurons just below the subplate. NMDAR (N-methyl-D-aspartate receptor)-mediated synaptic transmission from subplate neurons to multipolar neurons induces themultipolar-to-bipolar transition, leading to a change inmigration mode from slow multipolar migration to faster radial glial-guided locomotion. Our data suggested that transient synapses formed on early immature neurons regulate radialmigration.

Original languageEnglish
Pages (from-to)313-317
Number of pages5
JournalScience
Volume360
Issue number6386
DOIs
Publication statusPublished - 2018 Apr 20

ASJC Scopus subject areas

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    Ohtaka-Maruyama, C., Okamoto, M., Endo, K., Oshima, M., Kaneko, N., Yura, K., Okado, H., Miyata, T., & Maeda, N. (2018). Synaptic transmission from subplate neurons controls radial migration of neocortical neurons. Science, 360(6386), 313-317. https://doi.org/10.1126/science.aar2866