Synergism of Ce (IV) and Pr(III) for the fastest non-enzymatic DNA hydrolysis ever.

Naoya Takeda, M. Irisawa, T. Imai, M. Yashiro, M. Komiyama

Research output: Contribution to journalArticle

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Abstract

By the synergistic catalysis of Ce4+ and Pr3+, DNA is efficiently hydrolyzed at so far the highest rate. When [Ce4+] = 10 mM and [Pr3+] = 5 mM, the half-life of dinucleotide hydrolysis at pH 7 and 50 degrees C is only 24 min. This catalytic activity is 9 times as large as that of Ce4+, which is the only prominent catalyst hitherto reported. The Ce(4+)-Nd3+ combination is also effective. These bimetallic catalytic systems are eminent tools for the future molecular biology and biotechnology.

Original languageEnglish
Pages (from-to)207-208
Number of pages2
JournalNucleic acids symposium series
Issue number34
Publication statusPublished - 1995
Externally publishedYes

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Biotechnology
Catalysis
Half-Life
Molecular Biology
Hydrolysis
DNA
tetraconazole

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Synergism of Ce (IV) and Pr(III) for the fastest non-enzymatic DNA hydrolysis ever. / Takeda, Naoya; Irisawa, M.; Imai, T.; Yashiro, M.; Komiyama, M.

In: Nucleic acids symposium series, No. 34, 1995, p. 207-208.

Research output: Contribution to journalArticle

Takeda, Naoya ; Irisawa, M. ; Imai, T. ; Yashiro, M. ; Komiyama, M. / Synergism of Ce (IV) and Pr(III) for the fastest non-enzymatic DNA hydrolysis ever. In: Nucleic acids symposium series. 1995 ; No. 34. pp. 207-208.
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