Synergistic effects of stellated fibrous mesoporous silica and synthetic dsRNA analogues for cancer immunotherapy

Xiupeng Wang, Xia Li, Atsuo Ito, Yu Sogo, Yohei Watanabe, Kaoru Hashimoto, Atsushi Yamazaki, Tadao Ohno, Noriko M. Tsuji

    Research output: Contribution to journalArticle

    7 Citations (Scopus)

    Abstract

    Stellated fibrous mesoporous silica nanospheres significantly improve the cellular uptake of cancer antigen and the maturation of bone marrow derived dendritic cells in vitro. Moreover, the combination of poly(I:C) with stellated fibrous MS nanospheres markedly decreases the necessary dose of poly(I:C) for anti-tumor immunity, and thus opens new opportunities for the future clinical application of poly(I:C) in cancer immunotherapy.

    Original languageEnglish
    Pages (from-to)1057-1060
    Number of pages4
    JournalChemical Communications
    Volume54
    Issue number9
    DOIs
    Publication statusPublished - 2018 Jan 1

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    ASJC Scopus subject areas

    • Catalysis
    • Electronic, Optical and Magnetic Materials
    • Ceramics and Composites
    • Chemistry(all)
    • Surfaces, Coatings and Films
    • Metals and Alloys
    • Materials Chemistry

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