Synergistic effects of stellated fibrous mesoporous silica and synthetic dsRNA analogues for cancer immunotherapy

Xiupeng Wang, Xia Li, Atsuo Ito, Yu Sogo, Yohei Watanabe, Kaoru Hashimoto, Atsushi Yamazaki, Tadao Ohno, Noriko M. Tsuji

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Stellated fibrous mesoporous silica nanospheres significantly improve the cellular uptake of cancer antigen and the maturation of bone marrow derived dendritic cells in vitro. Moreover, the combination of poly(I:C) with stellated fibrous MS nanospheres markedly decreases the necessary dose of poly(I:C) for anti-tumor immunity, and thus opens new opportunities for the future clinical application of poly(I:C) in cancer immunotherapy.

Original languageEnglish
Pages (from-to)1057-1060
Number of pages4
JournalChemical Communications
Volume54
Issue number9
DOIs
Publication statusPublished - 2018 Jan 1

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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