Syntheses and biological activities of selenium analogs of α-rat atrial natriuretic peptide

Takaki Koide, H. Itoh, A. Otaka, M. Furuya, Y. Kitajima, N. Fujii

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

α-Rat atrial natriuretic peptide (7-28) (rANP (7-28)) and a series of its analogs in which half cystine residue(s) were substituted with half selenocystine residue(s) were synthesized by using the Fmoc-based solid- phase method followed by cyclization by means of dimethylsulfoxide (DMSO)- trifluoroacetic acid (TFA) oxidation. These analogs possess comparable activities in both receptor binding and cGMP accumulation in rat vascular smooth muscle cells to those of rAMP (7-28).

Original languageEnglish
Pages (from-to)1596-1600
Number of pages5
JournalChemical and Pharmaceutical Bulletin
Volume41
Issue number9
Publication statusPublished - 1993
Externally publishedYes

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ASJC Scopus subject areas

  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

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