α-Rat atrial natriuretic peptide (7-28) (rANP (7-28)) and a series of its analogs in which half cystine residue(s) were substituted with half selenocystine residue(s) were synthesized by using the Fmoc-based solid- phase method followed by cyclization by means of dimethylsulfoxide (DMSO)- trifluoroacetic acid (TFA) oxidation. These analogs possess comparable activities in both receptor binding and cGMP accumulation in rat vascular smooth muscle cells to those of rAMP (7-28).
|Number of pages||5|
|Journal||Chemical and Pharmaceutical Bulletin|
|Publication status||Published - 1993|
ASJC Scopus subject areas
- Organic Chemistry
- Drug Discovery