Syntheses and Biological Activities of Selenium Analogs of α-Rat Atrial Natriuretic Peptide1)

Takaki Koide, Hiromi Itoh, Akira Otaka, Nobutaka Fuji, Mayumi Furuya, Yasuo Kitajima

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

a-Rat atrial natriuretic peptide (7—28) (rANP (7—28)) and a series of its analogs in which half cystine residue(s) were substituted with half selenocystine residue(s) were synthesized by using the Fmoc-based solid-phase method followed by cyclization by means of dimethylsulfoxide (DMSO)-trifluoroacetic acid (TFA) oxidation. These analogs possess comparable activities in both receptor binding and cGMP accumulation in rat vascular smooth muscle cells to those of rAMP (7—28).

Original languageEnglish
Pages (from-to)1596-1600
Number of pages5
JournalChemical and Pharmaceutical Bulletin
Volume41
Issue number9
DOIs
Publication statusPublished - 1993
Externally publishedYes

Keywords

  • Fmoc-based solid-phase peptide synthesis
  • atrial natriuretic peptide
  • cyclic GMP
  • dimethylsulfoxide
  • selenocystine

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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