Syntheses and biological activities of selenium analogs of α-rat atrial natriuretic peptide

Takaki Koide, H. Itoh, A. Otaka, M. Furuya, Y. Kitajima, N. Fujii

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

α-Rat atrial natriuretic peptide (7-28) (rANP (7-28)) and a series of its analogs in which half cystine residue(s) were substituted with half selenocystine residue(s) were synthesized by using the Fmoc-based solid- phase method followed by cyclization by means of dimethylsulfoxide (DMSO)- trifluoroacetic acid (TFA) oxidation. These analogs possess comparable activities in both receptor binding and cGMP accumulation in rat vascular smooth muscle cells to those of rAMP (7-28).

Original languageEnglish
Pages (from-to)1596-1600
Number of pages5
JournalChemical and Pharmaceutical Bulletin
Volume41
Issue number9
Publication statusPublished - 1993
Externally publishedYes

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Trifluoroacetic Acid
Cyclization
Selenium
Dimethyl Sulfoxide
Bioactivity
Vascular Smooth Muscle
Smooth Muscle Myocytes
Cysteine
Muscle
Rats
Cells
Oxidation
rat atrial natriuretic peptide
selenocystine
cyclic GMP-binding protein

ASJC Scopus subject areas

  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Syntheses and biological activities of selenium analogs of α-rat atrial natriuretic peptide. / Koide, Takaki; Itoh, H.; Otaka, A.; Furuya, M.; Kitajima, Y.; Fujii, N.

In: Chemical and Pharmaceutical Bulletin, Vol. 41, No. 9, 1993, p. 1596-1600.

Research output: Contribution to journalArticle

Koide, T, Itoh, H, Otaka, A, Furuya, M, Kitajima, Y & Fujii, N 1993, 'Syntheses and biological activities of selenium analogs of α-rat atrial natriuretic peptide', Chemical and Pharmaceutical Bulletin, vol. 41, no. 9, pp. 1596-1600.
Koide, Takaki ; Itoh, H. ; Otaka, A. ; Furuya, M. ; Kitajima, Y. ; Fujii, N. / Syntheses and biological activities of selenium analogs of α-rat atrial natriuretic peptide. In: Chemical and Pharmaceutical Bulletin. 1993 ; Vol. 41, No. 9. pp. 1596-1600.
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