Synthesis and biological activity of 5-(4-methoxyphenyl)-oxazole derivatives

Daisuke Yamamuro, Ryuji Uchida, Masaki Ohtawa, Shiho Arima, Yushi Futamura, Masumi Katane, Hiroshi Homma, Tohru Nagamitsu, Hiroyuki Osada, Hiroshi Tomoda*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

5-(4′-Methoxyphenyl)-oxazole (MPO), originally reported as a synthetic compound, was isolated from fungal culture broth as an inhibitor of hatch and growth of Caenorhabditis elegans. Nineteen MPO derivatives were chemically synthesized, but showed no effect on C. elegans hatch and growth. These findings strongly suggested that the whole structure of MPO is essential for anti-C. elegans activity.

Original languageEnglish
Pages (from-to)313-316
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume25
Issue number2
DOIs
Publication statusPublished - 2015 Jan 15
Externally publishedYes

Keywords

  • 5-(4′-Methoxyphenyl)-oxazole
  • Caenorhabditis elegans
  • Hatch inhibition

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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