TY - JOUR
T1 - Synthesis and biological activity of 5-(4-methoxyphenyl)-oxazole derivatives
AU - Yamamuro, Daisuke
AU - Uchida, Ryuji
AU - Ohtawa, Masaki
AU - Arima, Shiho
AU - Futamura, Yushi
AU - Katane, Masumi
AU - Homma, Hiroshi
AU - Nagamitsu, Tohru
AU - Osada, Hiroyuki
AU - Tomoda, Hiroshi
N1 - Funding Information:
We thank Dr. Kenichiro Nagai and Ms. Noriko Sato of the School of Pharmacy, Kitasato University for measurements of mass spectra and NMR spectra. This study was partially supported by a Grant from the 22nd Sasagawa Scientific Research (to D.Y.).
Publisher Copyright:
© 2014 Elsevier Ltd. All rights reserved.
PY - 2015/1/15
Y1 - 2015/1/15
N2 - 5-(4′-Methoxyphenyl)-oxazole (MPO), originally reported as a synthetic compound, was isolated from fungal culture broth as an inhibitor of hatch and growth of Caenorhabditis elegans. Nineteen MPO derivatives were chemically synthesized, but showed no effect on C. elegans hatch and growth. These findings strongly suggested that the whole structure of MPO is essential for anti-C. elegans activity.
AB - 5-(4′-Methoxyphenyl)-oxazole (MPO), originally reported as a synthetic compound, was isolated from fungal culture broth as an inhibitor of hatch and growth of Caenorhabditis elegans. Nineteen MPO derivatives were chemically synthesized, but showed no effect on C. elegans hatch and growth. These findings strongly suggested that the whole structure of MPO is essential for anti-C. elegans activity.
KW - 5-(4′-Methoxyphenyl)-oxazole
KW - Caenorhabditis elegans
KW - Hatch inhibition
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U2 - 10.1016/j.bmcl.2014.11.042
DO - 10.1016/j.bmcl.2014.11.042
M3 - Article
C2 - 25488842
AN - SCOPUS:84922329034
SN - 0960-894X
VL - 25
SP - 313
EP - 316
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 2
ER -