Synthesis and biological evaluation of molecular probes based on the 9-methylstreptimidone derivative DTCM-glutarimide

Eisuke Ota, Masatoshi Takeiri, Miyuki Tachibana, Yuichi Ishikawa, Kazuo Umezawa, Shigeru Nishiyama

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Molecular probes based on 3-[(dodecylthiocarbonyl)methyl]glutarimide (DTCM-glutarimide) were synthesized and assessed for inhibitory activity against LPS-induced NO production. Among the probes examined, several derivatives exhibited potential for use in determining the target proteins of DTCM-glutarimide.

Original languageEnglish
Pages (from-to)164-167
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume22
Issue number1
DOIs
Publication statusPublished - 2012 Jan 1
Externally publishedYes

Fingerprint

Molecular Probes
Derivatives
Proteins
3-((dodecylthiocarbonyl)methyl)glutarimide
9-methylstreptimidone

Keywords

  • 9-Methylstreptimidone
  • Molecular probe
  • NF-κB
  • Streptomyces sp

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Synthesis and biological evaluation of molecular probes based on the 9-methylstreptimidone derivative DTCM-glutarimide. / Ota, Eisuke; Takeiri, Masatoshi; Tachibana, Miyuki; Ishikawa, Yuichi; Umezawa, Kazuo; Nishiyama, Shigeru.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 22, No. 1, 01.01.2012, p. 164-167.

Research output: Contribution to journalArticle

Ota, Eisuke ; Takeiri, Masatoshi ; Tachibana, Miyuki ; Ishikawa, Yuichi ; Umezawa, Kazuo ; Nishiyama, Shigeru. / Synthesis and biological evaluation of molecular probes based on the 9-methylstreptimidone derivative DTCM-glutarimide. In: Bioorganic and Medicinal Chemistry Letters. 2012 ; Vol. 22, No. 1. pp. 164-167.
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