Abstract
In this study, a series of electrochemically active oligo(ethylene glycol) (OEG) linear-dendrons have been synthesized and grafted onto electrode surfaces by cyclic voltammetry (CV) to improve protein resistance. Dendronized molecules with peripheral carbazole functionality and branching architecture enabled tethering of the poly(ethylene glycol) (PEG) or OEG group with a predictable number of electrochemical reactive groups affecting OEG distribution and orientation. It is possible that ample spacing between the OEG chains affects the intrinsic hydration of these layers and thus surface protein resistance. The films were characterized by CV, surface plasmon resonance (SPR), static contact angle measurements, and atomic force microscopy (AFM). This approach should enable improved nonbiofouling properties on biorelevant electrode surfaces (metal or metal oxides) by potentiostatic or potentiodynamic electrochemical methods, providing an alternative to the self-assembled monolayer (SAM) approach for anchoring PEG layers.
| Original language | English |
|---|---|
| Pages (from-to) | 3401-3405 |
| Number of pages | 5 |
| Journal | ACS Applied Materials and Interfaces |
| Volume | 2 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 2010 Dec 22 |
| Externally published | Yes |
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Keywords
- adsorption
- electrochemical
- electrografting
- OEG
- PEG
- protein resistance
- SPR
ASJC Scopus subject areas
- Materials Science(all)
Cite this
Synthesis and electrografting of dendron anchored OEGylated surfaces and their protein adsorption resistance. / Felipe, Mary Jane L; Ponnapati, Ramakrishna R.; Pernites, Roderick B.; Dutta, Pampa; Advincula, Rigoberto C.
In: ACS Applied Materials and Interfaces, Vol. 2, No. 12, 22.12.2010, p. 3401-3405.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthesis and electrografting of dendron anchored OEGylated surfaces and their protein adsorption resistance
AU - Felipe, Mary Jane L
AU - Ponnapati, Ramakrishna R.
AU - Pernites, Roderick B.
AU - Dutta, Pampa
AU - Advincula, Rigoberto C.
PY - 2010/12/22
Y1 - 2010/12/22
N2 - In this study, a series of electrochemically active oligo(ethylene glycol) (OEG) linear-dendrons have been synthesized and grafted onto electrode surfaces by cyclic voltammetry (CV) to improve protein resistance. Dendronized molecules with peripheral carbazole functionality and branching architecture enabled tethering of the poly(ethylene glycol) (PEG) or OEG group with a predictable number of electrochemical reactive groups affecting OEG distribution and orientation. It is possible that ample spacing between the OEG chains affects the intrinsic hydration of these layers and thus surface protein resistance. The films were characterized by CV, surface plasmon resonance (SPR), static contact angle measurements, and atomic force microscopy (AFM). This approach should enable improved nonbiofouling properties on biorelevant electrode surfaces (metal or metal oxides) by potentiostatic or potentiodynamic electrochemical methods, providing an alternative to the self-assembled monolayer (SAM) approach for anchoring PEG layers.
AB - In this study, a series of electrochemically active oligo(ethylene glycol) (OEG) linear-dendrons have been synthesized and grafted onto electrode surfaces by cyclic voltammetry (CV) to improve protein resistance. Dendronized molecules with peripheral carbazole functionality and branching architecture enabled tethering of the poly(ethylene glycol) (PEG) or OEG group with a predictable number of electrochemical reactive groups affecting OEG distribution and orientation. It is possible that ample spacing between the OEG chains affects the intrinsic hydration of these layers and thus surface protein resistance. The films were characterized by CV, surface plasmon resonance (SPR), static contact angle measurements, and atomic force microscopy (AFM). This approach should enable improved nonbiofouling properties on biorelevant electrode surfaces (metal or metal oxides) by potentiostatic or potentiodynamic electrochemical methods, providing an alternative to the self-assembled monolayer (SAM) approach for anchoring PEG layers.
KW - adsorption
KW - electrochemical
KW - electrografting
KW - OEG
KW - PEG
KW - protein resistance
KW - SPR
UR - http://www.scopus.com/inward/record.url?scp=79151478848&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79151478848&partnerID=8YFLogxK
U2 - 10.1021/am100737s
DO - 10.1021/am100737s
M3 - Article
C2 - 21077629
AN - SCOPUS:79151478848
VL - 2
SP - 3401
EP - 3405
JO - ACS applied materials & interfaces
JF - ACS applied materials & interfaces
SN - 1944-8244
IS - 12
ER -