Synthesis and kinetic cyclisation of quinine-derived oligomers

Stuart J. Rowan, Paul A. Brady, Jeremy K M Sanders

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The synthesis and kinetic cyclisations of a series of linear quinine oligomers are described. The distribution of cyclic oligomers is different from that observed in the corresponding thermodynamic cyclisation: cyclic tetramer is observed in the kinetic cyclisations, indicating that its absence under thermodynamic conditions is not due to any kinetic barrier to its formation.

Original languageEnglish
Pages (from-to)6013-6016
Number of pages4
JournalTetrahedron Letters
Volume37
Issue number33
DOIs
Publication statusPublished - 1996 Aug 12
Externally publishedYes

Fingerprint

Quinine
Cyclization
Oligomers
Thermodynamics
Kinetics

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Synthesis and kinetic cyclisation of quinine-derived oligomers. / Rowan, Stuart J.; Brady, Paul A.; Sanders, Jeremy K M.

In: Tetrahedron Letters, Vol. 37, No. 33, 12.08.1996, p. 6013-6016.

Research output: Contribution to journalArticle

Rowan, Stuart J. ; Brady, Paul A. ; Sanders, Jeremy K M. / Synthesis and kinetic cyclisation of quinine-derived oligomers. In: Tetrahedron Letters. 1996 ; Vol. 37, No. 33. pp. 6013-6016.
@article{67c8f3e7ac12468d9a0fbeb3e218d307,
title = "Synthesis and kinetic cyclisation of quinine-derived oligomers",
abstract = "The synthesis and kinetic cyclisations of a series of linear quinine oligomers are described. The distribution of cyclic oligomers is different from that observed in the corresponding thermodynamic cyclisation: cyclic tetramer is observed in the kinetic cyclisations, indicating that its absence under thermodynamic conditions is not due to any kinetic barrier to its formation.",
author = "Rowan, {Stuart J.} and Brady, {Paul A.} and Sanders, {Jeremy K M}",
year = "1996",
month = "8",
day = "12",
doi = "10.1016/0040-4039(96)01263-4",
language = "English",
volume = "37",
pages = "6013--6016",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "33",

}

TY - JOUR

T1 - Synthesis and kinetic cyclisation of quinine-derived oligomers

AU - Rowan, Stuart J.

AU - Brady, Paul A.

AU - Sanders, Jeremy K M

PY - 1996/8/12

Y1 - 1996/8/12

N2 - The synthesis and kinetic cyclisations of a series of linear quinine oligomers are described. The distribution of cyclic oligomers is different from that observed in the corresponding thermodynamic cyclisation: cyclic tetramer is observed in the kinetic cyclisations, indicating that its absence under thermodynamic conditions is not due to any kinetic barrier to its formation.

AB - The synthesis and kinetic cyclisations of a series of linear quinine oligomers are described. The distribution of cyclic oligomers is different from that observed in the corresponding thermodynamic cyclisation: cyclic tetramer is observed in the kinetic cyclisations, indicating that its absence under thermodynamic conditions is not due to any kinetic barrier to its formation.

UR - http://www.scopus.com/inward/record.url?scp=0030581328&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030581328&partnerID=8YFLogxK

U2 - 10.1016/0040-4039(96)01263-4

DO - 10.1016/0040-4039(96)01263-4

M3 - Article

AN - SCOPUS:0030581328

VL - 37

SP - 6013

EP - 6016

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 33

ER -