Synthesis and structure - anti-tumor-promoting activity relationship of monogalactosyl diacylglycerols

Akito Nagatsu, Miyako Watanabe, Kouji Ikemoto, Masayo Hashimoto, Nobutoshi Murakami, Jinsaki Sakakibara, Harukuni Tokuda, Hoyoku Nishino, Akio Iwashima, Kazunaga Yazawa

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Monogalactosyl diacylglycerols (MGDG, 1a-t) were synthesized utilizing p-methoxybenzyl group for protection of hydroxyl groups at sugar moiety. Inhibitory activity of MGDG (1a-t) and related compounds on Epstein-Barr virus early antigen activation was evaluated as anti-tumor-promoting activity, and MGDG with oleoyl group (1c,h-j,p,s) showed strong activity.

Original languageEnglish
Pages (from-to)1619-1622
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume4
Issue number13
DOIs
Publication statusPublished - 1994 Jul 7
Externally publishedYes

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Diglycerides
Sugars
Hydroxyl Radical
Tumors
Chemical activation
Neoplasms
Epstein-Barr virus early antigen

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Nagatsu, A., Watanabe, M., Ikemoto, K., Hashimoto, M., Murakami, N., Sakakibara, J., ... Yazawa, K. (1994). Synthesis and structure - anti-tumor-promoting activity relationship of monogalactosyl diacylglycerols. Bioorganic and Medicinal Chemistry Letters, 4(13), 1619-1622. https://doi.org/10.1016/S0960-894X(01)80577-1

Synthesis and structure - anti-tumor-promoting activity relationship of monogalactosyl diacylglycerols. / Nagatsu, Akito; Watanabe, Miyako; Ikemoto, Kouji; Hashimoto, Masayo; Murakami, Nobutoshi; Sakakibara, Jinsaki; Tokuda, Harukuni; Nishino, Hoyoku; Iwashima, Akio; Yazawa, Kazunaga.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 4, No. 13, 07.07.1994, p. 1619-1622.

Research output: Contribution to journalArticle

Nagatsu, A, Watanabe, M, Ikemoto, K, Hashimoto, M, Murakami, N, Sakakibara, J, Tokuda, H, Nishino, H, Iwashima, A & Yazawa, K 1994, 'Synthesis and structure - anti-tumor-promoting activity relationship of monogalactosyl diacylglycerols', Bioorganic and Medicinal Chemistry Letters, vol. 4, no. 13, pp. 1619-1622. https://doi.org/10.1016/S0960-894X(01)80577-1
Nagatsu, Akito ; Watanabe, Miyako ; Ikemoto, Kouji ; Hashimoto, Masayo ; Murakami, Nobutoshi ; Sakakibara, Jinsaki ; Tokuda, Harukuni ; Nishino, Hoyoku ; Iwashima, Akio ; Yazawa, Kazunaga. / Synthesis and structure - anti-tumor-promoting activity relationship of monogalactosyl diacylglycerols. In: Bioorganic and Medicinal Chemistry Letters. 1994 ; Vol. 4, No. 13. pp. 1619-1622.
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