Synthesis and structure formation in dilute aqueous solution of a chitosan-DNA hybrid

Ilyès Safir, Kien Xuan Ngo, Jancy Nixon Abraham, Majid Ghahraman Afshar, Ewa Pavlova, Corinne Nardin

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

In the following is described the combination of straight biochemical and organic routes to graft nucleotide sequences to a chitosan backbone. The resulting chitosan-g-ssDNA hybrid self-assembles into submicrometer size structures in dilute aqueous solution as assessed by atomic force and electron microscopy imaging. The hypothesis of self-assembly driven by chemical incompatibility between the amphiphilic chitosan and nucleic acid grafts is supported further by stability of the self-assembly against ionic strength and pH variations.

Original languageEnglish
Pages (from-to)29-36
Number of pages8
JournalPolymer (United Kingdom)
Volume79
DOIs
Publication statusPublished - 2015 Nov 19
Externally publishedYes

Keywords

  • Chitosan
  • DNA
  • Self-assembly

ASJC Scopus subject areas

  • Polymers and Plastics
  • Organic Chemistry

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  • Cite this

    Safir, I., Ngo, K. X., Nixon Abraham, J., Ghahraman Afshar, M., Pavlova, E., & Nardin, C. (2015). Synthesis and structure formation in dilute aqueous solution of a chitosan-DNA hybrid. Polymer (United Kingdom), 79, 29-36. https://doi.org/10.1016/j.polymer.2015.09.072