Synthesis of β-amino ketones by iridium(III)-catalyzed direct-Mannich reaction

Shunsuke Sueki; Takeyuki Igarashi; Takayuki Nakajima; Isao Shimizu

doi:10.1246/cl.2006.682

Synthesis of β-amino ketones by iridium(III)-catalyzed direct-Mannich reaction

Shunsuke Sueki, Takeyuki Igarashi, Takayuki Nakajima, Isao Shimizu^*

^*Corresponding author for this work

Waseda University

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

The direct-Mannich reaction of ketones 1, aldehydes 2, and anilines 3 was studied using catalytic amount of transition-metal complexes. The trivalent iridium complex, [IrCl₂(H)(COd)]₂, catalyzed the direct-Mannich reaction effectively to give various β-amino kenotes in good yields under mild conditions.

Original language	English
Pages (from-to)	682-683
Number of pages	2
Journal	Chemistry Letters
Volume	35
Issue number	6
DOIs	https://doi.org/10.1246/cl.2006.682
Publication status	Published - 2006 Jun 5

ASJC Scopus subject areas

Chemistry(all)

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abstract = "The direct-Mannich reaction of ketones 1, aldehydes 2, and anilines 3 was studied using catalytic amount of transition-metal complexes. The trivalent iridium complex, [IrCl2(H)(COd)]2, catalyzed the direct-Mannich reaction effectively to give various β-amino kenotes in good yields under mild conditions.",

author = "Shunsuke Sueki and Takeyuki Igarashi and Takayuki Nakajima and Isao Shimizu",

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AU - Igarashi, Takeyuki

AU - Nakajima, Takayuki

AU - Shimizu, Isao

PY - 2006/6/5

Y1 - 2006/6/5

N2 - The direct-Mannich reaction of ketones 1, aldehydes 2, and anilines 3 was studied using catalytic amount of transition-metal complexes. The trivalent iridium complex, [IrCl2(H)(COd)]2, catalyzed the direct-Mannich reaction effectively to give various β-amino kenotes in good yields under mild conditions.

AB - The direct-Mannich reaction of ketones 1, aldehydes 2, and anilines 3 was studied using catalytic amount of transition-metal complexes. The trivalent iridium complex, [IrCl2(H)(COd)]2, catalyzed the direct-Mannich reaction effectively to give various β-amino kenotes in good yields under mild conditions.

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Synthesis of β-amino ketones by iridium(III)-catalyzed direct-Mannich reaction

Abstract

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