Synthesis of a heptaarylisoquinoline

Unusual disconnection for constructing isoquinoline frameworks

Takashi Asako, Shin Suzuki, Kenichiro Itami, Kei Muto, Junichiro Yamaguchi

Research output: Contribution to journalArticle

Abstract

In a novel disconnection of isoquinoline ring synthesis at the C7C8/C4aC8a bonds, these bonds can be formed by a [4+2] cycloaddition between thiophene S,S-dioxide and alkynes. With a subsequent CH arylation of the resulting hexaarylisoquinoline at the C3 position, the synthesis of a fully substituted isoquinoline has been achieved.

Original languageEnglish
Pages (from-to)968-970
Number of pages3
JournalChemistry Letters
Volume47
Issue number8
DOIs
Publication statusPublished - 2018 Jan 1

Fingerprint

Thiophenes
Alkynes
Cycloaddition
isoquinoline

Keywords

  • Heterocycle
  • Isoquinoline
  • [4+2] cycloaddition

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Synthesis of a heptaarylisoquinoline : Unusual disconnection for constructing isoquinoline frameworks. / Asako, Takashi; Suzuki, Shin; Itami, Kenichiro; Muto, Kei; Yamaguchi, Junichiro.

In: Chemistry Letters, Vol. 47, No. 8, 01.01.2018, p. 968-970.

Research output: Contribution to journalArticle

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