Synthesis of albumin/DCP nano-composite particles

Hajime Ohsawa, Atsuo Ito, Yu Sogo, Atsushi Yamazaki, Tadao Ohno

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Highly disgregated dicalcium phosphate anhydrate (DCP) nanoparticles 240-367 nm in diameter were synthesized by a reaction between calcium carbonate and phosphoric acid. When the DCP nanoparticles were immersed in a supersaturated calcium phosphate solution containing bovine serum albumin (BSA) and ethanol, BSA/DCP nano-composite particles were synthesized through the coprecipitation of BSA on the DCP nanoparticles. BSA was firmly immobilized on the BSA/DCP nano-composite particles. The results of this study suggest that DCP nanoparticles appear to be useful as a drug delivery vehicle.

Original languageEnglish
Pages (from-to)239-242
Number of pages4
JournalKey Engineering Materials
Volume330-332 I
DOIs
Publication statusPublished - 2007 Jan 1

Keywords

  • Bovine serum albumin
  • Coprecipitation
  • Dicalcium phosphate an hydrate
  • Drug delivery vehicle
  • Nano particles

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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