Synthesis of albumin/DCP nano-composite particles

Hajime Ohsawa, Atsuo Ito, Yu Sogo, Atsushi Yamazaki, Tadao Ohno

    Research output: Contribution to journalArticle

    9 Citations (Scopus)

    Abstract

    Highly disgregated dicalcium phosphate anhydrate (DCP) nanoparticles 240-367 nm in diameter were synthesized by a reaction between calcium carbonate and phosphoric acid. When the DCP nanoparticles were immersed in a supersaturated calcium phosphate solution containing bovine serum albumin (BSA) and ethanol, BSA/DCP nano-composite particles were synthesized through the coprecipitation of BSA on the DCP nanoparticles. BSA was firmly immobilized on the BSA/DCP nano-composite particles. The results of this study suggest that DCP nanoparticles appear to be useful as a drug delivery vehicle.

    Original languageEnglish
    Pages (from-to)239-242
    Number of pages4
    JournalKey Engineering Materials
    Volume330-332 I
    Publication statusPublished - 2007

    Fingerprint

    Bovine Serum Albumin
    Albumins
    Phosphates
    Composite materials
    Nanoparticles
    Calcium Carbonate
    Calcium phosphate
    Calcium carbonate
    Phosphoric acid
    Coprecipitation
    Drug delivery
    anhydrous dibasic calcium phosphate
    Ethanol

    Keywords

    • Bovine serum albumin
    • Coprecipitation
    • Dicalcium phosphate an hydrate
    • Drug delivery vehicle
    • Nano particles

    ASJC Scopus subject areas

    • Ceramics and Composites
    • Chemical Engineering (miscellaneous)

    Cite this

    Ohsawa, H., Ito, A., Sogo, Y., Yamazaki, A., & Ohno, T. (2007). Synthesis of albumin/DCP nano-composite particles. Key Engineering Materials, 330-332 I, 239-242.

    Synthesis of albumin/DCP nano-composite particles. / Ohsawa, Hajime; Ito, Atsuo; Sogo, Yu; Yamazaki, Atsushi; Ohno, Tadao.

    In: Key Engineering Materials, Vol. 330-332 I, 2007, p. 239-242.

    Research output: Contribution to journalArticle

    Ohsawa, H, Ito, A, Sogo, Y, Yamazaki, A & Ohno, T 2007, 'Synthesis of albumin/DCP nano-composite particles', Key Engineering Materials, vol. 330-332 I, pp. 239-242.
    Ohsawa H, Ito A, Sogo Y, Yamazaki A, Ohno T. Synthesis of albumin/DCP nano-composite particles. Key Engineering Materials. 2007;330-332 I:239-242.
    Ohsawa, Hajime ; Ito, Atsuo ; Sogo, Yu ; Yamazaki, Atsushi ; Ohno, Tadao. / Synthesis of albumin/DCP nano-composite particles. In: Key Engineering Materials. 2007 ; Vol. 330-332 I. pp. 239-242.
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