Synthesis of alkylsulfonio-porphyrin complexes and its anti-cancer and anti-oxidant properties

Masayasu Komuro, Ryota Awa, Yuji Ito, Aritomo Yamaguchi, Kenichi Oyaizu, Makoto Yuasa

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In living body, oxygen (O2) generates reactives oxygen species (ROS) such as superoxide anion radical (O2 - ·). Living body has superoxide dismutase (SOD) enzyme for elimination of ROS. However, decrese of activity of SOD causes inflammation, cancer, and other deseases. In this study, we synthesized metalloporphyrins as anti-oxidant and anti-cancer drug. Novel alkylsulfonioporphyrin complexes were synthesized. It was revealed that they were effective as anti-oxidant and as anti-cancer agents, by stopped-flow method and cell viability tests, respectively.

Original languageEnglish
Title of host publicationPolymer Preprints, Japan
Pages2288
Number of pages1
Volume54
Edition1
Publication statusPublished - 2005
Externally publishedYes
Event54th SPSJ Annual Meeting 2005 - Yokohama
Duration: 2005 May 252005 May 27

Other

Other54th SPSJ Annual Meeting 2005
CityYokohama
Period05/5/2505/5/27

Fingerprint

Porphyrins
Oxidants
Oxygen
Negative ions
Enzymes
Cells
Superoxide Dismutase

Keywords

  • Alkylsulfonioporphyrin
  • Anti-cancer
  • Anti-oxidant
  • SOD model

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Komuro, M., Awa, R., Ito, Y., Yamaguchi, A., Oyaizu, K., & Yuasa, M. (2005). Synthesis of alkylsulfonio-porphyrin complexes and its anti-cancer and anti-oxidant properties. In Polymer Preprints, Japan (1 ed., Vol. 54, pp. 2288)

Synthesis of alkylsulfonio-porphyrin complexes and its anti-cancer and anti-oxidant properties. / Komuro, Masayasu; Awa, Ryota; Ito, Yuji; Yamaguchi, Aritomo; Oyaizu, Kenichi; Yuasa, Makoto.

Polymer Preprints, Japan. Vol. 54 1. ed. 2005. p. 2288.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Komuro, M, Awa, R, Ito, Y, Yamaguchi, A, Oyaizu, K & Yuasa, M 2005, Synthesis of alkylsulfonio-porphyrin complexes and its anti-cancer and anti-oxidant properties. in Polymer Preprints, Japan. 1 edn, vol. 54, pp. 2288, 54th SPSJ Annual Meeting 2005, Yokohama, 05/5/25.
Komuro M, Awa R, Ito Y, Yamaguchi A, Oyaizu K, Yuasa M. Synthesis of alkylsulfonio-porphyrin complexes and its anti-cancer and anti-oxidant properties. In Polymer Preprints, Japan. 1 ed. Vol. 54. 2005. p. 2288
Komuro, Masayasu ; Awa, Ryota ; Ito, Yuji ; Yamaguchi, Aritomo ; Oyaizu, Kenichi ; Yuasa, Makoto. / Synthesis of alkylsulfonio-porphyrin complexes and its anti-cancer and anti-oxidant properties. Polymer Preprints, Japan. Vol. 54 1. ed. 2005. pp. 2288
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