Synthesis of alkylsulfonio-porphyrin complexes and its anti-cancer and anti-oxidant properties

Masayasu Komuro, Ryota Awa, Yuji Ito, Aritomo Yamaguchi, Kenichi Oyaizu, Makoto Yuasa

Research output: Contribution to conferencePaper

Abstract

In living body, oxygen (O2) generates reactives oxygen species (ROS) such as superoxide anion radical (O2- ·). Living body has superoxide dismutase (SOD) enzyme for elimination of ROS. However, decrese of activity of SOD causes inflammation, cancer, and other deseases. In this study, we synthesized metalloporphyrins as anti-oxidant and anti-cancer drug. Novel alkylsulfonioporphyrin complexes were synthesized. It was revealed that they were effective as anti-oxidant and as anti-cancer agents, by stopped-flow method and cell viability tests, respectively.

Original languageEnglish
Number of pages1
Publication statusPublished - 2005 Dec 1
Event54th SPSJ Annual Meeting 2005 - Yokohama, Japan
Duration: 2005 May 252005 May 27

Conference

Conference54th SPSJ Annual Meeting 2005
CountryJapan
CityYokohama
Period05/5/2505/5/27

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Keywords

  • Alkylsulfonioporphyrin
  • Anti-cancer
  • Anti-oxidant
  • SOD model

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Komuro, M., Awa, R., Ito, Y., Yamaguchi, A., Oyaizu, K., & Yuasa, M. (2005). Synthesis of alkylsulfonio-porphyrin complexes and its anti-cancer and anti-oxidant properties. Paper presented at 54th SPSJ Annual Meeting 2005, Yokohama, Japan.