Synthesis of amphiphilic block copolymers bearing stable nitroxyl radicals

Xiuli Zhuang, Chunsheng Xiao, Kenichi Oyaizu, Natsuru Chikushi, Xuesi Chen, Hiroyuki Nishide

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

We present here the synthesis of two kinds of amphiphilic block copolymers, a diblock copolymer MPEG-b-PTAm and a triblock copolymer MPEG-b-PLA-b-PTAm, which can self-assemble into micelles with nitroxyl radicals-containing PTAm segment in the core. The structure of the block copolymers was characterized by 1H NMR and GPC. Dynamic laser light scattering and transmission electron microscopy were used to study the micellar behavior of the two block copolymers in aqueous solution. The micelles carrying nitroxyl radicals in the core can generate electron paramagnetic resonance, which is stable for a period of time up to 8 min even in the presence of reducing reagent such as ascorbic acid. The enhanced stability against the reducing agent was ascribed to the inaccessibility of the nitroxyl radical core placed in the interior of the micelles. Combined with the biocompatibility, these micelles were promising to be used as the EPR probes for bioimaging in vivo.

Original languageEnglish
Pages (from-to)5404-5410
Number of pages7
JournalJournal of Polymer Science, Part A: Polymer Chemistry
Volume48
Issue number23
DOIs
Publication statusPublished - 2010 Dec 1

Fingerprint

Bearings (structural)
Block copolymers
Micelles
Paramagnetic resonance
Ascorbic acid
Reducing Agents
Reducing agents
Light transmission
Biocompatibility
Light scattering
Ascorbic Acid
Nuclear magnetic resonance
nitroxyl
Transmission electron microscopy
Lasers

Keywords

  • Bioimaging
  • Block copolymers
  • ESR/EPR
  • Micelles
  • Nitroxyl radical

ASJC Scopus subject areas

  • Materials Chemistry
  • Polymers and Plastics
  • Organic Chemistry

Cite this

Synthesis of amphiphilic block copolymers bearing stable nitroxyl radicals. / Zhuang, Xiuli; Xiao, Chunsheng; Oyaizu, Kenichi; Chikushi, Natsuru; Chen, Xuesi; Nishide, Hiroyuki.

In: Journal of Polymer Science, Part A: Polymer Chemistry, Vol. 48, No. 23, 01.12.2010, p. 5404-5410.

Research output: Contribution to journalArticle

Zhuang, Xiuli ; Xiao, Chunsheng ; Oyaizu, Kenichi ; Chikushi, Natsuru ; Chen, Xuesi ; Nishide, Hiroyuki. / Synthesis of amphiphilic block copolymers bearing stable nitroxyl radicals. In: Journal of Polymer Science, Part A: Polymer Chemistry. 2010 ; Vol. 48, No. 23. pp. 5404-5410.
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