Synthesis of cationic aminolipids and characteristic of cationic liposome

Yosuke Obata, Shinji Takeoka

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    The development of new gene delivery technologies is required using novel nonviral lipid. In this paper, we synthesized new cationic lipids from amino acids. Our synthesized cationic lipids have glutamic acid skeleton at hydrophobic part and have amino acid such as lysine and histidine, arginine at hydrophilic part. We investigated physicochemical properties of the lipid assemblies. This synthesized lipids formed vesicle in water. We reported the synthetic methods of new cationic lipids and evaluated characteristics of cationic lipids with TEM and fluorescent-labeled method. Furthermore, we preparated cationic liposome using the synthesized amino lipids as a part of membrane components.

    Original languageEnglish
    Title of host publicationPolymer Preprints, Japan
    Pages2131
    Number of pages1
    Volume54
    Edition1
    Publication statusPublished - 2005
    Event54th SPSJ Annual Meeting 2005 - Yokohama
    Duration: 2005 May 252005 May 27

    Other

    Other54th SPSJ Annual Meeting 2005
    CityYokohama
    Period05/5/2505/5/27

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    Keywords

    • Amino lipid
    • Cationic liposome
    • Drug delivery

    ASJC Scopus subject areas

    • Engineering(all)

    Cite this

    Obata, Y., & Takeoka, S. (2005). Synthesis of cationic aminolipids and characteristic of cationic liposome. In Polymer Preprints, Japan (1 ed., Vol. 54, pp. 2131)