Synthesis of cationic aminolipids and characteristic of cationic liposome

Yosuke Obata, Shinii Takeoka

Research output: Contribution to conferencePaperpeer-review

Abstract

The development of new gene delivery technologies is required using novel nonviral lipid. In this paper, we synthesized new cationic lipids from amino acids. Our synthesized cationic lipids have glutamic acid skeleton at hydrophobic part and have amino acid such as lysine and histidine, arginine at hydrophilic part. We investigated physicochemical properties of the lipid assemblies. This synthesized lipids formed vesicle in water. We reported the synthetic methods of new cationic lipids and evaluated characteristics of cationic lipids with TEM and fluorescent-labeled method. Furthermore, we preparated cationic liposome using the synthesized amino lipids as a part of membrane components.

Original languageEnglish
Number of pages1
Publication statusPublished - 2005 Dec 1
Event54th SPSJ Annual Meeting 2005 - Yokohama, Japan
Duration: 2005 May 252005 May 27

Conference

Conference54th SPSJ Annual Meeting 2005
CountryJapan
CityYokohama
Period05/5/2505/5/27

Keywords

  • Amino lipid
  • Cationic liposome
  • Drug delivery

ASJC Scopus subject areas

  • Engineering(all)

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